1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2,4-difluoro-5-iodobenzene

Base Information

Chemical Name:1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2,4-difluoro-5-iodobenzene
CAS No.:333447-80-6
Molecular Formula:C₂₅H₁₇Cl₂F₂IO₅
Molecular Weight:633.214
Hs Code.:

Synonyms:1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2,4-difluoro-5-iodobenzene

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Chemical Property of 1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2,4-difluoro-5-iodobenzene

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Technology Process of 1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2,4-difluoro-5-iodobenzene

There total 4 articles about 1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2,4-difluoro-5-iodobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 333447-44-2
1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2,4-difluorobenzene

: 333447-80-6
1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2,4-difluoro-5-iodobenzene

Guidance literature:: With N-iodo-succinimide; In trifluoroacetic acid; at 25 ℃; for 20h;
DOI:10.1081/NCN-100001435

Reference yield:

: 348-57-2
2,4-difluorobromobenzene

: 333447-80-6
1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2,4-difluoro-5-iodobenzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: Mg; I₂ / tetrahydrofuran / 1 h / 40 °C

1.2: CdCl₂ / 1 h / Heating

1.3: 64 percent / 12 h / 25 °C

2.1: 85 percent / N-iodosuccinimide / trifluoroacetic acid / 20 h / 25 °C

With N-iodo-succinimide; iodine; magnesium; In tetrahydrofuran; trifluoroacetic acid;
DOI:10.1081/NCN-100001435

Reference yield:

: 122-01-0
4-chloro-benzoyl chloride

: 333447-80-6
1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2,4-difluoro-5-iodobenzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: AcCl; MeOH / 0.75 h / 25 °C

1.2: pyridine; DMAP / 0 - 25 °C

1.3: 82 percent / HCl gas / diethyl ether; acetic acid / 0.17 h / 0 °C

2.1: Mg; I₂ / tetrahydrofuran / 1 h / 40 °C

2.2: CdCl₂ / 1 h / Heating

2.3: 64 percent / 12 h / 25 °C

3.1: 85 percent / N-iodosuccinimide / trifluoroacetic acid / 20 h / 25 °C

With methanol; N-iodo-succinimide; iodine; magnesium; acetyl chloride; In tetrahydrofuran; trifluoroacetic acid;
DOI:10.1081/NCN-100001435