(1S,2S)-1-Allyl-2-(tetrahydro-pyran-2-yloxy)-cyclohexanecarboxylic acid ethyl ester

Base Information

Chemical Name:(1S,2S)-1-Allyl-2-(tetrahydro-pyran-2-yloxy)-cyclohexanecarboxylic acid ethyl ester
CAS No.:863506-60-9
Molecular Formula:C₁₇H₂₈O₄
Molecular Weight:296.407
Hs Code.:

Synonyms:(1S,2S)-1-Allyl-2-(tetrahydro-pyran-2-yloxy)-cyclohexanecarboxylic acid ethyl ester

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Chemical Property of (1S,2S)-1-Allyl-2-(tetrahydro-pyran-2-yloxy)-cyclohexanecarboxylic acid ethyl ester

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Technology Process of (1S,2S)-1-Allyl-2-(tetrahydro-pyran-2-yloxy)-cyclohexanecarboxylic acid ethyl ester

There total 4 articles about (1S,2S)-1-Allyl-2-(tetrahydro-pyran-2-yloxy)-cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 76948-07-7
(-)-(1S,2S)-1-Allyl-2-hydroxy-cyclohexancarbonsaeureaethylester

: 863506-60-9
(1S,2S)-1-Allyl-2-(tetrahydro-pyran-2-yloxy)-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane;
DOI:10.1055/s-2005-871555

Reference yield:

: 61586-78-5
ethyl (1R,2S)-2-hydroxycyclohexane-1-carboxylate

: 863506-60-9
(1S,2S)-1-Allyl-2-(tetrahydro-pyran-2-yloxy)-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran / 0.5 h / -60 - -15 °C

1.2: 90 percent / tetrahydrofuran / 4.5 h / -15 - 20 °C

2.1: 95 percent / p-TsOH / CH₂Cl₂

With toluene-4-sulfonic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-2005-871555

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 863506-60-9
(1S,2S)-1-Allyl-2-(tetrahydro-pyran-2-yloxy)-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 62 percent / NaH / benzene / 1.5 h / Heating

2.1: 76 percent / baker's yeast Saccharomyces cerevisiae; aq. sucrose

3.1: LDA / tetrahydrofuran / 0.5 h / -60 - -15 °C

3.2: 90 percent / tetrahydrofuran / 4.5 h / -15 - 20 °C

4.1: 95 percent / p-TsOH / CH₂Cl₂

With baker's yeast Saccharomyces cerevisiae; sodium hydride; toluene-4-sulfonic acid; lithium diisopropyl amide; Sucrose; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1055/s-2005-871555