(E)-3-[4-(4-Fluoro-benzoyl)-1-methyl-1H-pyrrol-2-yl]-acrylic acid ethyl ester

Base Information

Chemical Name:(E)-3-[4-(4-Fluoro-benzoyl)-1-methyl-1H-pyrrol-2-yl]-acrylic acid ethyl ester
CAS No.:128843-41-4
Molecular Formula:C₁₇H₁₆FNO₃
Molecular Weight:301.317
Hs Code.:

Synonyms:(E)-3-[4-(4-Fluoro-benzoyl)-1-methyl-1H-pyrrol-2-yl]-acrylic acid ethyl ester

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Chemical Property of (E)-3-[4-(4-Fluoro-benzoyl)-1-methyl-1H-pyrrol-2-yl]-acrylic acid ethyl ester

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Technology Process of (E)-3-[4-(4-Fluoro-benzoyl)-1-methyl-1H-pyrrol-2-yl]-acrylic acid ethyl ester

There total 4 articles about (E)-3-[4-(4-Fluoro-benzoyl)-1-methyl-1H-pyrrol-2-yl]-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 128843-61-8
4-(4-fluorobenzoyl)-1-methyl-1H-pyrrole-2-carboxaldehyde

: 128843-41-4
(E)-3-[4-(4-Fluoro-benzoyl)-1-methyl-1H-pyrrol-2-yl]-acrylic acid ethyl ester

Guidance literature:: With potassium carbonate; In ethanol;
DOI:10.1021/jm00172a026

Reference yield:

: 96-54-8
N-Methylpyrrole

: 128843-41-4
(E)-3-[4-(4-Fluoro-benzoyl)-1-methyl-1H-pyrrol-2-yl]-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride / 1,2-dichloro-ethane / 0.25 h / 20 °C

2: AlCl₃ / 1,2-dichloro-ethane / 3 h

3: K₂CO₃ / ethanol / 2 h / 70 °C

With aluminium trichloride; oxalyl dichloride; potassium carbonate; In ethanol; 1,2-dichloro-ethane; 1: Vilsmeier-Haack reaction / 2: Friedel-Crafts reaction / 3: Wittig-Horner reaction;
DOI:10.1021/jm021070e

Reference yield:

: 403-43-0
4-fluorobenzoyl chloride

: 128843-41-4
(E)-3-[4-(4-Fluoro-benzoyl)-1-methyl-1H-pyrrol-2-yl]-acrylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: (COCl)2 / 1,2-dichloro-ethane / 0 °C

1.2: AlCl₃ / 1,2-dichloro-ethane / 20 °C

1.3: 50percent aq. NaOH / 1,2-dichloro-ethane / 20 °C

2.1: K₂CO₃ / ethanol / 80 °C

With oxalyl dichloride; potassium carbonate; In ethanol; 1,2-dichloro-ethane; 1.2: Friedel-Crafts reaction / 2.1: Wittig-Horner reaction;
DOI:10.1021/jm015515v