trans-1-tert-butoxycarbonylamino-4-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)cyclohexane

Base Information

Chemical Name:trans-1-tert-butoxycarbonylamino-4-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)cyclohexane
CAS No.:776297-89-3
Molecular Formula:C₂₇H₄₈N₄O₉
Molecular Weight:572.7
Hs Code.:

Synonyms:trans-1-tert-butoxycarbonylamino-4-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)cyclohexane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of trans-1-tert-butoxycarbonylamino-4-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)cyclohexane

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Technology Process of trans-1-tert-butoxycarbonylamino-4-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)cyclohexane

There total 1 articles about trans-1-tert-butoxycarbonylamino-4-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 177906-48-8
trans-N-Boc-1,4-cyclohexanediamine

: [[2-(bis-ethoxycarbonylmethyl-amino)-ethyl]-(2-isobutoxycarbonyloxy-2-oxo-ethyl)-amino]-acetic acid ethyl ester

: 776297-89-3
trans-1-tert-butoxycarbonylamino-4-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)cyclohexane

Guidance literature:: In tetrahydrofuran; at 4 ℃; for 18h;
DOI:10.1055/s-2004-829143

Reference yield: 81.0%

: 776297-89-3
trans-1-tert-butoxycarbonylamino-4-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)cyclohexane

: 776297-90-6
trans-1-amino-4-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)cyclohexane

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 18 ℃; for 0.5h;
DOI:10.1055/s-2004-829143

Reference yield:

: 776297-89-3
trans-1-tert-butoxycarbonylamino-4-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)cyclohexane

: 776297-87-1
N⁴-[trans-4-(2-{[2-bis(ethoxycarbonylmethylamino)ethyl]ethoxycarbonylmethylamino}acetylamino)cyclohexyl]-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / TFA / CH₂Cl₂ / 0.5 h / 18 °C

2: 75 percent / ethanol / 1 h / 60 °C

3: 83 percent / TBAF / tetrahydrofuran / 18 h / 18 °C

With tetrabutyl ammonium fluoride; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1055/s-2004-829143