5-amino-4-(2,2-dicyanovinyl)-1-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-ribofuranosyl)imidazole

Base Information

Chemical Name:5-amino-4-(2,2-dicyanovinyl)-1-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-ribofuranosyl)imidazole
CAS No.:482359-42-2
Molecular Formula:C₂₈H₂₅N₅O₅
Molecular Weight:511.537
Hs Code.:

Synonyms:5-amino-4-(2,2-dicyanovinyl)-1-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-ribofuranosyl)imidazole

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Chemical Property of 5-amino-4-(2,2-dicyanovinyl)-1-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-ribofuranosyl)imidazole

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Technology Process of 5-amino-4-(2,2-dicyanovinyl)-1-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-ribofuranosyl)imidazole

There total 3 articles about 5-amino-4-(2,2-dicyanovinyl)-1-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-ribofuranosyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 123-06-8
Ethoxymethylenemalononitrile

: 482359-41-1
5-amino-1-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-ribofuranosyl)imidazole

: 482359-42-2
5-amino-4-(2,2-dicyanovinyl)-1-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-ribofuranosyl)imidazole

Guidance literature:: In tetrahydrofuran; at 50 ℃; under 103.432 - 206.865 Torr; Inert atmosphere;
DOI:10.3998/ark.5550190.p010.075

Reference yield:

: 4330-21-6
2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

: 482359-42-2
5-amino-4-(2,2-dicyanovinyl)-1-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-ribofuranosyl)imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 3 h

2: H₂ / 5 percent Pd/C / tetrahydrofuran / 2 h

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; acetonitrile;
DOI:10.1055/s-2002-33505

Reference yield:

: 482359-34-2
1-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-5-nitroimidazole

: 482359-42-2
5-amino-4-(2,2-dicyanovinyl)-1-(2'-deoxy-3',5'-di-O-p-toluoyl-β-D-ribofuranosyl)imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 5 percent Pd/C / tetrahydrofuran / 2 h

With hydrogen; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1055/s-2002-33505