methanesulfonic acid 2-fluoro-6-(4-methoxy-benzylamino)-pyridin-4-ylmethyl ester

Base Information

• Chemical Name: methanesulfonic acid 2-fluoro-6-(4-methoxy-benzylamino)-pyridin-4-ylmethyl ester
• CAS No.: 1006300-20-4
• Molecular Formula: C₁₅H₁₇FN₂O₄S
• Molecular Weight: 340.375

Synonyms:methanesulfonic acid 2-fluoro-6-(4-methoxy-benzylamino)-pyridin-4-ylmethyl ester

Chemical Property of methanesulfonic acid 2-fluoro-6-(4-methoxy-benzylamino)-pyridin-4-ylmethyl ester

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Technology Process of methanesulfonic acid 2-fluoro-6-(4-methoxy-benzylamino)-pyridin-4-ylmethyl ester

There total 1 articles about methanesulfonic acid 2-fluoro-6-(4-methoxy-benzylamino)-pyridin-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[2-Fluoro-6-(4-methoxy-benzylamino)-pyridin-4-yl]-methanol (1006300-69-1) + methanesulfonyl chloride (124-63-0) → methanesulfonic acid 2-fluoro-6-(4-methoxy-benzylamino)-pyridin-4-ylmethyl ester (1006300-20-4)

Guidance literature:

With triethylamine; In chloroform; at 0 ℃; for 1.1 - 1.5h; Product distribution / selectivity;

Reference yield: 49.0%

methanesulfonic acid 2-fluoro-6-(4-methoxy-benzylamino)-pyridin-4-ylmethyl ester (1006300-20-4) + 3-(5-isopropenyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carbonyl)-5-methyl-benzonitrile (1006302-50-6) → 3-{3-[2-fluoro-6-(4-methoxy-benzylamino)-pyridin-4-ylmethyl]-5-isopropenyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carbonyl}-5-methyl-benzonitrile

Guidance literature:

With potassium carbonate; lithium iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 8h;

Reference yield: 46.0%

methanesulfonic acid 2-fluoro-6-(4-methoxy-benzylamino)-pyridin-4-ylmethyl ester (1006300-20-4) + 3-[3-(5-isopropyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yloxy)-5-methyl-phenyl]-acrylonitrile (1006300-21-5) → (E)-3-(3-{3-[2-fluoro-6-(4-methoxy-benzylamino)-pyridin-4-ylmethyl]-5-isopropyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yloxy}-5-methyl-phenyl)-acrylonitrile (1006300-19-1)

Guidance literature:

With potassium carbonate; lithium iodide; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

[2-Fluoro-6-(4-methoxy-benzylamino)-pyridin-4-yl]-methanol

methanesulfonyl chloride

Downstream raw materials:

(E)-3-(3-{3-[2-fluoro-6-(4-methoxy-benzylamino)-pyridin-4-ylmethyl]-5-isopropyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yloxy}-5-methyl-phenyl)-acrylonitrile

6-(3,5-dimethyl-benzoyl)-1-[2-fluoro-6-(4-methoxy-benzylamino)-pyridin-4-ylmethyl]-5-isopropyl-1H-pyrimidine-2,4-dione

6-(3-bromo-5-methyl-benzoyl)-1-[2-fluoro-6-(4-methoxy-benzylamino)-pyridin-4-ylmethyl]-5-isopropyl-1H-pyrimidine-2,4-dione

3-{3-[2-Fluoro-6-(4-methoxy-benzylamino)-pyridin-4-ylmethyl]-5-isopropyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yloxy}-5-methyl-benzonitrile

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