C₃₇H₄₀FN₄O₁₂P

Base Information

• Chemical Name: C₃₇H₄₀FN₄O₁₂P
• CAS No.: 1315584-56-5
• Molecular Formula: C₃₇H₄₀FN₄O₁₂P
• Molecular Weight: 782.716
• Mol file: 1315584-56-5.mol

Synonyms:C₃₇H₄₀FN₄O₁₂P

Chemical Property of C₃₇H₄₀FN₄O₁₂P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of C₃₇H₄₀FN₄O₁₂P

There total 4 articles about C₃₇H₄₀FN₄O₁₂P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C26H26FN3O8 (1315584-55-4) + (2S)-ethyl 2-(chloro(phenoxy)phosphorylamino)propanoate (245078-14-2) → C37H40FN4O12P (1315584-56-5)

Guidance literature:

With 1-methyl-1H-imidazole; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2011.05.046

Reference yield:

C32H40FN3O8Si (1315584-53-2) → C37H40FN4O12P (1315584-56-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: 1-methyl-1H-imidazole / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

With 1-methyl-1H-imidazole; triethylamine tris(hydrogen fluoride); In tetrahydrofuran;

DOI:10.1016/j.tet.2011.05.046

Reference yield:

(2'R)-2'-deoxy-2'-fluoro-2'-methylcytidine (817204-33-4) → C37H40FN4O12P (1315584-56-5)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine; 1H-imidazole / 0 - 20 °C / Inert atmosphere

2: dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

3: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: 1-methyl-1H-imidazole / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; 1-methyl-1H-imidazole; dmap; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tet.2011.05.046

upstream raw materials:

(2'R)-2'-deoxy-2'-fluoro-2'-methylcytidine

C₁₆H₂₈FN₃O₄Si

C₃₂H₄₀FN₃O₈Si

C₂₆H₂₆FN₃O₈

Downstream raw materials:

C₂₁H₂₈FN₄O₈P

Refernces