5-(di(tert-butoxycarbonyl)amino)-3-methoxypent-2-enoic pentafluorophenol ester

Base Information

Chemical Name:5-(di(tert-butoxycarbonyl)amino)-3-methoxypent-2-enoic pentafluorophenol ester
CAS No.:1333912-07-4
Molecular Formula:C₂₂H₂₆F₅NO₇
Molecular Weight:511.443
Hs Code.:

Synonyms:5-(di(tert-butoxycarbonyl)amino)-3-methoxypent-2-enoic pentafluorophenol ester

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Chemical Property of 5-(di(tert-butoxycarbonyl)amino)-3-methoxypent-2-enoic pentafluorophenol ester

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Technology Process of 5-(di(tert-butoxycarbonyl)amino)-3-methoxypent-2-enoic pentafluorophenol ester

There total 7 articles about 5-(di(tert-butoxycarbonyl)amino)-3-methoxypent-2-enoic pentafluorophenol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1333912-05-2
5-((tert-butoxycarbonyl)amino)-3-methoxypent-2-enoic pentafluorophenol ester

: 1333912-07-4
5-(di(tert-butoxycarbonyl)amino)-3-methoxypent-2-enoic pentafluorophenol ester

Guidance literature:: With dmap; In acetonitrile; at 20 ℃; for 7h; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.07.078

Reference yield:

: 1333912-04-1
5-((tert-butoxycarbonyl)amino)-3-methoxypent-2-enoic acid methyl ester

: 1333912-07-4
5-(di(tert-butoxycarbonyl)amino)-3-methoxypent-2-enoic pentafluorophenol ester

Guidance literature:: Multi-step reaction with 3 steps

1: water; lithium hydroxide / tetrahydrofuran / 43 h / 20 - 50 °C / Inert atmosphere

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / ethyl acetate / 25 h / 0 - 20 °C / Inert atmosphere

3: dmap / acetonitrile / 7 h / 20 °C / Inert atmosphere

With dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; ethyl acetate; acetonitrile;
DOI:10.1016/j.tetlet.2011.07.078

Reference yield:

: 1333911-91-3
5-((tert-butoxycarbonyl)amino)-3-methoxypent-2-enoic acid

: 1333912-07-4
5-(di(tert-butoxycarbonyl)amino)-3-methoxypent-2-enoic pentafluorophenol ester

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / ethyl acetate / 25 h / 0 - 20 °C / Inert atmosphere

2: dmap / acetonitrile / 7 h / 20 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethyl acetate; acetonitrile;
DOI:10.1016/j.tetlet.2011.07.078