3-benzyloxycarbonyl-5-(3-methansulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester

Base Information

Chemical Name:3-benzyloxycarbonyl-5-(3-methansulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester
CAS No.:116556-59-3
Molecular Formula:C₃₇H₄₅N₃O₈S
Molecular Weight:691.846
Hs Code.:

3-benzyloxycarbonyl-5-(3-methansulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester

Synonyms:3-benzyloxycarbonyl-5-(3-methansulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester

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Chemical Property of 3-benzyloxycarbonyl-5-(3-methansulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester

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Technology Process of 3-benzyloxycarbonyl-5-(3-methansulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester

There total 17 articles about 3-benzyloxycarbonyl-5-(3-methansulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 124-63-0
methanesulfonyl chloride

: 116556-58-2
3-benzyloxycarbonyl-5-(3-hydroxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester

: 116556-59-3
3-benzyloxycarbonyl-5-(3-methansulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; at -20 - 0 ℃; for 20h;
DOI:10.1016/S0040-4020(01)86862-9

Reference yield:

: 116527-79-8,116527-80-1
2-(3-benzyloxypropyl)-2,3,5,6,11,11b-hexahydro-1H-indolizino<8,7-b>indol

: 116556-59-3
3-benzyloxycarbonyl-5-(3-methansulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) water; / 1.) aceton; 2.) 50 deg C, 1 h

2: 68 percent / HCl / CH₂Cl₂ / 2 h / Ambient temperature

3: 97 percent / H₂, Pd/C / ethyl acetate; propan-2-ol / 24 h / 40 - 50 °C / Heating

4: sodium hydrogencarbonate, water / CH₂Cl₂ / 2 h

5: 72 percent / triethylamine / CH₂Cl₂ / 15 h / Ambient temperature

6: triethylamine, tert.-butylhypochlorite / CCl₄; CH₂Cl₂ / 0 °C

7: trifluoroborate-diethyletherate, sodium hydrogencarbonate / 1.25 h / Ambient temperature; Heating

With hydrogenchloride; palladium on activated charcoal; tert-butylhypochlorite; boron trifluoride diethyl etherate; water; hydrogen; sodium hydrogencarbonate; triethylamine; In tetrachloromethane; dichloromethane; ethyl acetate; isopropyl alcohol;
DOI:10.1016/S0040-4020(01)86862-9

Reference yield:

: 116527-78-7,116556-53-7
2-(3-benzyloxypropyl)-2,3,5,6,11,11b-hexahydro-1H-indolizino<8,7-b>indol-3-on

: 116556-59-3
3-benzyloxycarbonyl-5-(3-methansulphoxypropyl)-7-(4-dimethylamino-2-methoxyphenyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indol-7-carbonsauremethylester

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / Lithium aluminium hydride / tetrahydrofuran / 1 h / Heating

2: 1.) water; / 1.) aceton; 2.) 50 deg C, 1 h

3: 68 percent / HCl / CH₂Cl₂ / 2 h / Ambient temperature

4: 97 percent / H₂, Pd/C / ethyl acetate; propan-2-ol / 24 h / 40 - 50 °C / Heating

5: sodium hydrogencarbonate, water / CH₂Cl₂ / 2 h

6: 72 percent / triethylamine / CH₂Cl₂ / 15 h / Ambient temperature

7: triethylamine, tert.-butylhypochlorite / CCl₄; CH₂Cl₂ / 0 °C

8: trifluoroborate-diethyletherate, sodium hydrogencarbonate / 1.25 h / Ambient temperature; Heating

With hydrogenchloride; palladium on activated charcoal; lithium aluminium tetrahydride; tert-butylhypochlorite; boron trifluoride diethyl etherate; water; hydrogen; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane; ethyl acetate; isopropyl alcohol;
DOI:10.1016/S0040-4020(01)86862-9