methyl 4-[2-(1-benzhydryl-2-{2-[(benzylsulfonyl)(methyl)amino]ethyl}-5-chloro-1H-indol-3-yl)ethoxy]benzoate

Base Information

Chemical Name:methyl 4-[2-(1-benzhydryl-2-{2-[(benzylsulfonyl)(methyl)amino]ethyl}-5-chloro-1H-indol-3-yl)ethoxy]benzoate
CAS No.:934285-14-0
Molecular Formula:C₄₁H₃₉ClN₂O₅S
Molecular Weight:707.29
Hs Code.:

Synonyms:methyl 4-[2-(1-benzhydryl-2-{2-[(benzylsulfonyl)(methyl)amino]ethyl}-5-chloro-1H-indol-3-yl)ethoxy]benzoate

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Chemical Property of methyl 4-[2-(1-benzhydryl-2-{2-[(benzylsulfonyl)(methyl)amino]ethyl}-5-chloro-1H-indol-3-yl)ethoxy]benzoate

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Technology Process of methyl 4-[2-(1-benzhydryl-2-{2-[(benzylsulfonyl)(methyl)amino]ethyl}-5-chloro-1H-indol-3-yl)ethoxy]benzoate

There total 7 articles about methyl 4-[2-(1-benzhydryl-2-{2-[(benzylsulfonyl)(methyl)amino]ethyl}-5-chloro-1H-indol-3-yl)ethoxy]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 683812-86-4
methyl 4-[2-(1-benzhydryl-2-{2-[(benzylsulfonyl)amino]ethyl}-5-chloro-1H-indol-3-yl)ethoxy]benzoate

: 74-88-4
methyl iodide

: 934285-14-0
methyl 4-[2-(1-benzhydryl-2-{2-[(benzylsulfonyl)(methyl)amino]ethyl}-5-chloro-1H-indol-3-yl)ethoxy]benzoate

Guidance literature:: With silver(l) oxide;
DOI:10.1021/jm061131z

Reference yield:

: 479422-24-7
methyl 4-[2-[5-chloro-(1-diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]benzoate

: 934285-14-0
methyl 4-[2-(1-benzhydryl-2-{2-[(benzylsulfonyl)(methyl)amino]ethyl}-5-chloro-1H-indol-3-yl)ethoxy]benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: NBS; benzoyl peroxide / CCl₄ / 2.5 h / Heating

2: 0.750 g / Ag₂CO₃; H₂O / acetone

3: 23 percent / NH₄OAc / 4 h / Heating

4: 65 percent / Zn(Hg); aq. HCl / tetrahydrofuran / 1 h

5: 86 percent / aq. NaHCO₃ / CH₂Cl₂ / 1 h

6: 94 percent / Ag₂O

With hydrogenchloride; N-Bromosuccinimide; ammonium acetate; water; sodium hydrogencarbonate; silver carbonate; mercury; silver(l) oxide; zinc; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; acetone; 3: Henry reaction / 5: Schotten-Baumann reaction;
DOI:10.1021/jm061131z

Reference yield:

: 934284-96-5
methyl 4-(2-{5-chloro-1-(diphenylmethyl)-2-[(E)-2-nitrovinyl]-1H-indol-3-yl}ethoxy)benzoate

: 934285-14-0
methyl 4-[2-(1-benzhydryl-2-{2-[(benzylsulfonyl)(methyl)amino]ethyl}-5-chloro-1H-indol-3-yl)ethoxy]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / Zn(Hg); aq. HCl / tetrahydrofuran / 1 h

2: 86 percent / aq. NaHCO₃ / CH₂Cl₂ / 1 h

3: 94 percent / Ag₂O

With hydrogenchloride; sodium hydrogencarbonate; mercury; silver(l) oxide; zinc; In tetrahydrofuran; dichloromethane; 2: Schotten-Baumann reaction;
DOI:10.1021/jm061131z