8-(2'-deoxy-β-D-xylofuranosyl)-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine 3',5'-cyclic phosphate benzyl ester

Base Information

Chemical Name:8-(2'-deoxy-β-D-xylofuranosyl)-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine 3',5'-cyclic phosphate benzyl ester
CAS No.:476468-52-7
Molecular Formula:C₁₉H₂₂N₅O₅P
Molecular Weight:431.388
Hs Code.:

Synonyms:8-(2'-deoxy-β-D-xylofuranosyl)-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine 3',5'-cyclic phosphate benzyl ester

Suppliers and Price of 8-(2'-deoxy-β-D-xylofuranosyl)-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine 3',5'-cyclic phosphate benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 8-(2'-deoxy-β-D-xylofuranosyl)-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine 3',5'-cyclic phosphate benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-(2'-deoxy-β-D-xylofuranosyl)-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine 3',5'-cyclic phosphate benzyl ester

There total 8 articles about 8-(2'-deoxy-β-D-xylofuranosyl)-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine 3',5'-cyclic phosphate benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 990-91-0
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

: 476468-51-6
8-(2'-deoxy-β-D-xylofuranosyl)-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine

: 476468-52-7
8-(2'-deoxy-β-D-xylofuranosyl)-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine 3',5'-cyclic phosphate benzyl ester

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at -40 - 20 ℃;
DOI:10.1021/jo026268l

Reference yield:

: 55457-17-5
2-methylpyrazolo<1,5-a>-s-triazin-4-one

: 476468-52-7
8-(2'-deoxy-β-D-xylofuranosyl)-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine 3',5'-cyclic phosphate benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 87 percent / N,N-dimethylaniline; POCl₃ / 2 h / Heating

2: 1.46 g / CH₂Cl₂ / 0 - 20 °C

3: 87 percent / N-iodosuccinimide / CHCl₃ / 0.5 h / Heating

4: 75 percent / bis(dibenzylideneacetone)palladium⁽⁰⁾; Ph₃As; (n-Bu)3N / acetonitrile / 18 h / 60 °C

5: 78 percent / K-selectride / acetonitrile / 0.33 h / 20 °C

6: 67 percent / ethanol / 12 h / 100 °C

7: 63 percent / t-BuOK / tetrahydrofuran / -40 - 20 °C

With N-iodo-succinimide; tributyl-amine; triphenyl-arsane; potassium tert-butylate; potassium tri-sec-butyl-borohydride; N,N-dimethyl-aniline; bis(dibenzylideneacetone)-palladium⁽⁰⁾; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; chloroform; acetonitrile;
DOI:10.1021/jo026268l

Reference yield:

: 96761-00-1
1,4-anhydro-2-deoxy-D-erythro-pent-1-enitol

: 476468-52-7
8-(2'-deoxy-β-D-xylofuranosyl)-2-methyl-4-(N-methylamino)pyrazolo[1,5-a]-1,3,5-triazine 3',5'-cyclic phosphate benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / bis(dibenzylideneacetone)palladium⁽⁰⁾; Ph₃As; (n-Bu)3N / acetonitrile / 18 h / 60 °C

2: 78 percent / K-selectride / acetonitrile / 0.33 h / 20 °C

3: 67 percent / ethanol / 12 h / 100 °C

4: 63 percent / t-BuOK / tetrahydrofuran / -40 - 20 °C

With tributyl-amine; triphenyl-arsane; potassium tert-butylate; potassium tri-sec-butyl-borohydride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1021/jo026268l