2-chloro-(4S,5S)-bis{[(1S,2R,5S)-2-isopropyl-5-methylcyclohex-1-yl]oxycarbonyl}-1,3,2-dioxaphospholane

Base Information

• Chemical Name: 2-chloro-(4S,5S)-bis{[(1S,2R,5S)-2-isopropyl-5-methylcyclohex-1-yl]oxycarbonyl}-1,3,2-dioxaphospholane
• CAS No.: 1318682-88-0
• Molecular Formula: C₂₄H₄₀ClO₆P
• Molecular Weight: 491.005
• Mol file: 1318682-88-0.mol

Synonyms:2-chloro-(4S,5S)-bis{[(1S,2R,5S)-2-isopropyl-5-methylcyclohex-1-yl]oxycarbonyl}-1,3,2-dioxaphospholane

Chemical Property of 2-chloro-(4S,5S)-bis{[(1S,2R,5S)-2-isopropyl-5-methylcyclohex-1-yl]oxycarbonyl}-1,3,2-dioxaphospholane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-chloro-(4S,5S)-bis{[(1S,2R,5S)-2-isopropyl-5-methylcyclohex-1-yl]oxycarbonyl}-1,3,2-dioxaphospholane

There total 1 articles about 2-chloro-(4S,5S)-bis{[(1S,2R,5S)-2-isopropyl-5-methylcyclohex-1-yl]oxycarbonyl}-1,3,2-dioxaphospholane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

bis[(1S,2R,5S)-2-isopropyl-5-methylcyclohex-1-yl] (S,S)-tartrate (1318253-95-0,1287683-04-8) → 2-chloro-(4S,5S)-bis{[(1S,2R,5S)-2-isopropyl-5-methylcyclohex-1-yl]oxycarbonyl}-1,3,2-dioxaphospholane (1318682-88-0)

Guidance literature:

With phosphorus trichloride; In tetrahydrofuran; at 65 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tetasy.2011.04.004

Reference yield:

Tetrahydrofurfuryl alcohol (97-99-4) + 2-chloro-(4S,5S)-bis{[(1S,2R,5S)-2-isopropyl-5-methylcyclohex-1-yl]oxycarbonyl}-1,3,2-dioxaphospholane (1318682-88-0) → C29H49O8P (1318683-04-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; chloroform-d1; at 20 ℃;

DOI:10.1016/j.tetasy.2011.04.004

upstream raw materials:

bis[(1S,2R,5S)-2-isopropyl-5-methylcyclohex-1-yl] (S,S)-tartrate

Downstream raw materials:

C₂₉H₄₉O₈P