Trimethyl-{22-[4-((1E,3E,5E)-6-phenyl-hexa-1,3,5-trienyl)-phenyl]-docosyl}-ammonium; iodide

Base Information

• Chemical Name: Trimethyl-{22-[4-((1E,3E,5E)-6-phenyl-hexa-1,3,5-trienyl)-phenyl]-docosyl}-ammonium; iodide
• CAS No.: 134171-65-6
• Molecular Formula: C₄₃H₆₈N*I
• Molecular Weight: 725.924
• Mol file: 134171-65-6.mol

Synonyms:Trimethyl-{22-[4-((1E,3E,5E)-6-phenyl-hexa-1,3,5-trienyl)-phenyl]-docosyl}-ammonium; iodide

Chemical Property of Trimethyl-{22-[4-((1E,3E,5E)-6-phenyl-hexa-1,3,5-trienyl)-phenyl]-docosyl}-ammonium; iodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Trimethyl-{22-[4-((1E,3E,5E)-6-phenyl-hexa-1,3,5-trienyl)-phenyl]-docosyl}-ammonium; iodide

There total 15 articles about Trimethyl-{22-[4-((1E,3E,5E)-6-phenyl-hexa-1,3,5-trienyl)-phenyl]-docosyl}-ammonium; iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

Dimethyl-{22-[4-((1E,3E,5E)-6-phenyl-hexa-1,3,5-trienyl)-phenyl]-docosyl}-amine (134171-71-4) + methyl iodide (74-88-4) → Trimethyl-{22-[4-((1E,3E,5E)-6-phenyl-hexa-1,3,5-trienyl)-phenyl]-docosyl}-ammonium; iodide (134171-65-6)

Guidance literature:

In acetone; toluene; at 70 ℃; for 3h;

DOI:10.1016/S0040-4020(01)86422-X

Reference yield:

1,20-eicosanediol (7735-43-5) → Trimethyl-{22-[4-((1E,3E,5E)-6-phenyl-hexa-1,3,5-trienyl)-phenyl]-docosyl}-ammonium; iodide (134171-65-6)

Guidance literature:

Multi-step reaction with 10 steps

1: 49 percent / 48percent aq. HBr / petroleum ether / 24 h / Heating

2: PPTS / CH₂Cl₂ / 20 h / Ambient temperature

3: 1) lithium diisopropylamide / 1) THF, 0 deg C, 30 min, 2) THF, 30 min

4: 89 percent / tetrahydrofuran; diethyl ether / 0.25 h / 0 °C

5: 1) triphenylphosphine dibromide / 1) CH₂Cl₂, 30 min, 2) DMSO, reflux, 20 h

6: AlCl₃, LiAH₄ / tetrahydrofuran / 20 h / Ambient temperature

7: formic acid / H₂O / 20 h / Heating

8: CrO₃, pyridine / CH₂Cl₂ / 0.25 h / Ambient temperature

9: 48 percent / NaOCH₃ / tetrahydrofuran / 2 h / Ambient temperature

10: 86 percent / toluene; acetone / 3 h / 70 °C

With pyridine; chromium(VI) oxide; lithium aluminium tetrahydride; aluminium trichloride; formic acid; hydrogen bromide; sodium methylate; pyridinium p-toluenesulfonate; lithium diisopropyl amide; dibromotriphenylphosphorane; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone; toluene; Petroleum ether;

DOI:10.1016/S0040-4020(01)86422-X

Reference yield:

(2E, 4E)-5-phenylpenta-2,4-dienal (13466-40-5) → Trimethyl-{22-[4-((1E,3E,5E)-6-phenyl-hexa-1,3,5-trienyl)-phenyl]-docosyl}-ammonium; iodide (134171-65-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 97 percent / DIBAH / tetrahydrofuran / 2 h / Ambient temperature

2: PCl₃ / diethyl ether / 1) 0 deg C, 15 min, 2) room temperature, 10 h

3: 7 h / 130 °C

4: 48 percent / NaOCH₃ / tetrahydrofuran / 2 h / Ambient temperature

5: 86 percent / toluene; acetone / 3 h / 70 °C

With sodium methylate; diisobutylaluminium hydride; phosphorus trichloride; In tetrahydrofuran; diethyl ether; acetone; toluene;

DOI:10.1016/S0040-4020(01)86422-X

upstream raw materials:

Dimethyl-{22-[4-((1E,3E,5E)-6-phenyl-hexa-1,3,5-trienyl)-phenyl]-docosyl}-amine

methyl iodide

1,20-eicosanediol

(2E, 4E)-5-phenylpenta-2,4-dienal