1-(tert-butylamino)-2-(morpholinocarbonyl)-1,3-dioxobutan-2-yl 2-tosylacetate

Base Information

• Chemical Name: 1-(tert-butylamino)-2-(morpholinocarbonyl)-1,3-dioxobutan-2-yl 2-tosylacetate
• CAS No.: 1592250-57-1
• Molecular Formula: C₂₂H₃₀N₂O₈S
• Molecular Weight: 482.555

Synonyms:1-(tert-butylamino)-2-(morpholinocarbonyl)-1,3-dioxobutan-2-yl 2-tosylacetate

Chemical Property of 1-(tert-butylamino)-2-(morpholinocarbonyl)-1,3-dioxobutan-2-yl 2-tosylacetate

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Technology Process of 1-(tert-butylamino)-2-(morpholinocarbonyl)-1,3-dioxobutan-2-yl 2-tosylacetate

There total 7 articles about 1-(tert-butylamino)-2-(morpholinocarbonyl)-1,3-dioxobutan-2-yl 2-tosylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

tert-butylisonitrile (119072-55-8,7188-38-7) + 1-morpholinobutane-1,2,3-trione + tosylacetic acid (3937-96-0) → 1-(tert-butylamino)-2-(morpholinocarbonyl)-1,3-dioxobutan-2-yl 2-tosylacetate (1592250-57-1) + C22H30N2O8S (1592250-67-3)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.8h; regioselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201301548

Reference yield: 64.0%

tert-butylisonitrile (119072-55-8,7188-38-7) + 1-morpholinobutane-1,2,3-trione + tosylacetic acid (3937-96-0) → 1-(tert-butylamino)-2-(morpholinocarbonyl)-1,3-dioxobutan-2-yl 2-tosylacetate (1592250-57-1) + C22H30N2O8S (1592250-67-3) + methyl 5-(tert-butylcarbamoyl)-4-methyl-5-(morpholinocarbonyl)-2-oxo-2,5-dihydrofuran-3-carboxylate (1592250-78-6)

Guidance literature:

In toluene; at 20 ℃; for 0.7h; Overall yield = 88 %; regioselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201301548

Reference yield: 64.0%

tert-butylisonitrile (119072-55-8,7188-38-7) + 1-morpholinobutane-1,2,3-trione + tosylacetic acid (3937-96-0) → 1-(tert-butylamino)-2-(morpholinocarbonyl)-1,3-dioxobutan-2-yl 2-tosylacetate (1592250-57-1) + C22H30N2O8S (1592250-67-3) + N-tert-butyl-3-methyl-2-(morpholinocarbonyl)-5-oxo-4-tosyl-2,5-dihydrofuran-2-carboxamide (1592250-80-0)

Guidance literature:

In toluene; at 20 ℃; for 0.666667h; regioselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201301548

upstream raw materials:

tert-butylisonitrile

tosylacetic acid

1-(morpholin-4-yl)butane-1,3-dione

2-diazo-1-morpholinobutane-1,3-dione

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