dimethyl 4-benzoyl-6,8-dimethylquinoline-2,3-dicarboxylate

Base Information

• Chemical Name: dimethyl 4-benzoyl-6,8-dimethylquinoline-2,3-dicarboxylate
• CAS No.: 1374309-31-5
• Molecular Formula: C₂₂H₁₉NO₅
• Molecular Weight: 377.397
• Mol file: 1374309-31-5.mol

Synonyms:dimethyl 4-benzoyl-6,8-dimethylquinoline-2,3-dicarboxylate

Chemical Property of dimethyl 4-benzoyl-6,8-dimethylquinoline-2,3-dicarboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of dimethyl 4-benzoyl-6,8-dimethylquinoline-2,3-dicarboxylate

There total 3 articles about dimethyl 4-benzoyl-6,8-dimethylquinoline-2,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

dimethyl 2-[4,6-dimethyl-(E)-stilben-2-yl]aminofumarate → dimethyl 4-benzoyl-6,8-dimethylquinoline-2,3-dicarboxylate (1374309-31-5) + dimethyl 6,8-dimethylquinoline-2,3-dicarboxylate

Guidance literature:

With 1-methyl-pyrrolidin-2-one; oxygen; copper(l) chloride; In N,N-dimethyl acetamide; at 100 ℃; for 0.5h; under 760.051 Torr; chemoselective reaction;

DOI:10.1055/s-0034-1378870

Reference yield: 40.0%

2,4-dimethyl-6-(phenylethynyl)aniline (1374310-33-4) + dimethyl acetylenedicarboxylate (762-42-5) → dimethyl 4-benzoyl-6,8-dimethylquinoline-2,3-dicarboxylate (1374309-31-5)

Guidance literature:

With oxygen; copper(l) chloride; In N,N-dimethyl acetamide; at 100 ℃; under 760.051 Torr;

DOI:10.1021/ol300896h

Reference yield:

(E)-2-amino-3,5-dimethylstilbene (132589-34-5) + dimethyl acetylenedicarboxylate (762-42-5) → dimethyl 4-benzoyl-6,8-dimethylquinoline-2,3-dicarboxylate (1374309-31-5) + dimethyl 6,8-dimethylquinoline-2,3-dicarboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / methanol / 2 h / 20 °C

2: oxygen; copper(l) chloride; 1-methyl-pyrrolidin-2-one / N,N-dimethyl acetamide / 0.5 h / 100 °C / 760.05 Torr

With 1-methyl-pyrrolidin-2-one; oxygen; toluene-4-sulfonic acid; copper(l) chloride; In methanol; N,N-dimethyl acetamide;

DOI:10.1055/s-0034-1378870

upstream raw materials:

2,4-dimethyl-6-(phenylethynyl)aniline

dimethyl acetylenedicarboxylate

(E)-2-amino-3,5-dimethylstilbene