3-([1,1'-biphenyl]-2-yl)-7-((1-methylpiperidin-4-yl)oxy)-2H-chromen-2-one

Base Information

Chemical Name:3-([1,1'-biphenyl]-2-yl)-7-((1-methylpiperidin-4-yl)oxy)-2H-chromen-2-one
CAS No.:1361199-22-5
Molecular Formula:C₂₇H₂₅NO₃
Molecular Weight:411.5
Hs Code.:

Synonyms:3-([1,1'-biphenyl]-2-yl)-7-((1-methylpiperidin-4-yl)oxy)-2H-chromen-2-one

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Chemical Property of 3-([1,1'-biphenyl]-2-yl)-7-((1-methylpiperidin-4-yl)oxy)-2H-chromen-2-one

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Technology Process of 3-([1,1'-biphenyl]-2-yl)-7-((1-methylpiperidin-4-yl)oxy)-2H-chromen-2-one

There total 6 articles about 3-([1,1'-biphenyl]-2-yl)-7-((1-methylpiperidin-4-yl)oxy)-2H-chromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1361198-91-5
3-bromo-7-((1-methylpiperidin-4-yl)oxy)-2H-chromen-2-one

: 4688-76-0
2-Biphenylboronic acid

: 1361199-22-5
3-([1,1'-biphenyl]-2-yl)-7-((1-methylpiperidin-4-yl)oxy)-2H-chromen-2-one

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; at 80 ℃; for 12h;
DOI:10.1021/ml300018e

Reference yield:

: 106-52-5
N-methyl-4-hydroxypiperidine

: 1361199-22-5
3-([1,1'-biphenyl]-2-yl)-7-((1-methylpiperidin-4-yl)oxy)-2H-chromen-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane / 12 h / 80 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; 1: Mitsunobu reaction / 2: Suzuki coupling;
DOI:10.1021/ml300018e

Reference yield:

: 93-35-6
7-hydroxy-2H-chromen-2-one

: 1361199-22-5
3-([1,1'-biphenyl]-2-yl)-7-((1-methylpiperidin-4-yl)oxy)-2H-chromen-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / N,N-dimethyl-formamide / 4 h / 20 °C

2: N-Bromosuccinimide; sodium acetate / acetonitrile / 20 °C

3: boron tribromide / dichloromethane / 12 h / 0 °C / Reflux

4: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h

5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane / 12 h / 80 °C

With N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; di-isopropyl azodicarboxylate; sodium acetate; boron tribromide; sodium hydride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 4: Mitsunobu reaction / 5: Suzuki coupling;
DOI:10.1021/ml300018e