3-(2-nitrobenzoyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid ethyl ester

Base Information

• Chemical Name: 3-(2-nitrobenzoyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid ethyl ester
• CAS No.: 710300-13-3
• Molecular Formula: C₁₃H₁₃N₃O₅
• Molecular Weight: 291.263
• Mol file: 710300-13-3.mol

Synonyms:3-(2-nitrobenzoyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid ethyl ester

Chemical Property of 3-(2-nitrobenzoyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-(2-nitrobenzoyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid ethyl ester

There total 1 articles about 3-(2-nitrobenzoyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

diazoacetic acid ethyl ester (623-73-4) + 1-(2-nitrophenyl)prop-2-en-1-one (68165-36-6) → 3-(2-nitrobenzoyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid ethyl ester (710300-13-3)

Guidance literature:

With pyridine; In acetonitrile; for 10h;

DOI:10.1016/j.tet.2004.03.013

Reference yield: 99.0%

acetic anhydride (108-24-7) + 3-(2-nitrobenzoyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid ethyl ester (710300-13-3) → ethyl 1-acetyl-3-(2-nitrobenzoyl)-Δ2-pyrazoline-5-carboxylate (710300-74-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.tet.2004.03.013

Reference yield: 99.0%

Cyclobutanecarbonyl chloride (5006-22-4) + 3-(2-nitrobenzoyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acid ethyl ester (710300-13-3) → ethyl 1-cyclobutanecarbonyl-3-(2-nitrobenzoyl)-Δ2-pyrazoline-5-carboxylate (710300-87-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.tet.2004.03.013

upstream raw materials:

diazoacetic acid ethyl ester

1-(2-nitrophenyl)prop-2-en-1-one

Downstream raw materials:

ethyl 1-cyclopentanecarbonyl-3-(2-nitrobenzoyl)-Δ²-pyrazoline-5-carboxylate

ethyl 3-(2-nitrobenzoyl)-1-propionyl-Δ²-pyrazoline-5-carboxylate

ethyl 1-acetyl-3-(2-nitrobenzoyl)-Δ²-pyrazoline-5-carboxylate

ethyl 1-cyclopropanecarbonyl-3-(2-nitrobenzoyl)-Δ²-pyrazoline-5-carboxylate