N-(tert-butoxycarbonyl)-1,1,1-tris[(4-hydroxy-3-nitrophenyl)acetamidomethyl]methylamine

Base Information

• Chemical Name: N-(tert-butoxycarbonyl)-1,1,1-tris[(4-hydroxy-3-nitrophenyl)acetamidomethyl]methylamine
• CAS No.: 1345700-42-6
• Molecular Formula: C₃₃H₃₇N₇O₁₄
• Molecular Weight: 755.695
• Mol file: 1345700-42-6.mol

Synonyms:N-(tert-butoxycarbonyl)-1,1,1-tris[(4-hydroxy-3-nitrophenyl)acetamidomethyl]methylamine

Chemical Property of N-(tert-butoxycarbonyl)-1,1,1-tris[(4-hydroxy-3-nitrophenyl)acetamidomethyl]methylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tert-butoxycarbonyl)-1,1,1-tris[(4-hydroxy-3-nitrophenyl)acetamidomethyl]methylamine

There total 1 articles about N-(tert-butoxycarbonyl)-1,1,1-tris[(4-hydroxy-3-nitrophenyl)acetamidomethyl]methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (1,3-diazido-2-(azidomethyl)propan-2-yl)carbamate (1345700-40-4) → N-(tert-butoxycarbonyl)-1,1,1-tris[(4-hydroxy-3-nitrophenyl)acetamidomethyl]methylamine (1345700-42-6)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 8 h / 20 °C

2: triethylamine / methanol / 36 h / 20 °C / pH 9 / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; ethanol;

DOI:10.1055/s-0030-1260151

Reference yield: 95.0%

N-(tert-butoxycarbonyl)-1,1,1-tris[(4-hydroxy-3-nitrophenyl)acetamidomethyl]methylamine (1345700-42-6) → 1,1,1-tris[(4-hydroxy-3-nitrophenyl)acetamidomethyl]methylamine (1345700-43-7)

Guidance literature:

With water; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 8h;

DOI:10.1055/s-0030-1260151

Reference yield:

N-(tert-butoxycarbonyl)-1,1,1-tris[(4-hydroxy-3-nitrophenyl)acetamidomethyl]methylamine (1345700-42-6) → 3,4,5-tris{2-[2-(2-azidoethoxy)ethoxy]ethoxy}-N-{1,1,1-tris[(4-hydroxy-3-nitrophenyl)acetamidomethyl]methyl}benzamide (1345700-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: water; trifluoroacetic acid / dichloromethane / 8 h / 20 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2.2: 24 h / 20 °C / Inert atmosphere

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;

DOI:10.1055/s-0030-1260151

upstream raw materials:

tert-butyl (1,3-diazido-2-(azidomethyl)propan-2-yl)carbamate

Downstream raw materials:

3,4,5-tris{2-[2-(2-azidoethoxy)ethoxy]ethoxy}-N-{1,1,1-tris[(4-hydroxy-3-nitrophenyl)acetamidomethyl]methyl}benzamide

1,1,1-tris[(4-hydroxy-3-nitrophenyl)acetamidomethyl]methylamine