2-Chloro-N-(2,2-diphenylethyl)-adenosine 2',3',5'-tribenzoate

Base Information

• Chemical Name: 2-Chloro-N-(2,2-diphenylethyl)-adenosine 2',3',5'-tribenzoate
• CAS No.: 167298-18-2
• Molecular Formula: C₄₅H₃₆ClN₅O₇
• Molecular Weight: 794.263
• Mol file: 167298-18-2.mol

Synonyms:2-Chloro-N-(2,2-diphenylethyl)-adenosine 2',3',5'-tribenzoate

Chemical Property of 2-Chloro-N-(2,2-diphenylethyl)-adenosine 2',3',5'-tribenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Chloro-N-(2,2-diphenylethyl)-adenosine 2',3',5'-tribenzoate

There total 4 articles about 2-Chloro-N-(2,2-diphenylethyl)-adenosine 2',3',5'-tribenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-dichloro-9-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)-9H-purine + 2,2-Diphenylethylamine (3963-62-0) → 2-Chloro-N-(2,2-diphenylethyl)-adenosine 2',3',5'-tribenzoate (167298-18-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol;

Reference yield:

2,6 dichloropurine (5451-40-1) → 2-Chloro-N-(2,2-diphenylethyl)-adenosine 2',3',5'-tribenzoate (167298-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 140 °C

2: i-Pr₂NEt / propan-2-ol / Heating

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; 1: Condensation / 2: Substitution;

DOI:10.1016/S0960-894X(00)00017-2

Reference yield:

1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose (14215-97-5) → 2-Chloro-N-(2,2-diphenylethyl)-adenosine 2',3',5'-tribenzoate (167298-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 140 °C

2: i-Pr₂NEt / propan-2-ol / Heating

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; 1: Condensation / 2: Substitution;

DOI:10.1016/S0960-894X(00)00017-2

upstream raw materials:

(2R,3R,4R,5R)-2-((benzoyloxy)methyl)-5-(2,6-dichloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl dibenzoate

2,2-Diphenylethylamine

2,6 dichloropurine

1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose

Downstream raw materials:

(2R,3R,4S,5R)-2-[2-chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol

(3aS,4S,6R,6aR)-6-[6-(2,2-Diphenyl-ethylamino)-2-(2-piperidin-1-yl-ethylamino)-purin-9-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid ethylamide

1-Deoxy-1-[6-[(2,2-diphenylethyl)amino]-2-[[2-(1H-imidazol-4-yl)ethyl]amino]-9H-purin-9-yl]-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide

(3aS,4S,6R,6aR)-6-[2-Chloro-6-(2,2-diphenyl-ethylamino)-purin-9-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid ethylamide