Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]-

Base Information

• Chemical Name: Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]-
• CAS No.: 870544-59-5
• Molecular Formula: C₂₃H₂₂F₃N₃O₃
• Molecular Weight: 445.441
• Mol file: 870544-59-5.mol

Synonyms:1-(2-(2-(tert-butyl)phenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea

Chemical Property of Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]-

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

BPTU ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: BPTU is a non-nucleotide antagonist of P2Y1 receptor. It blocks nerve mediated inhibitory neuromuscular responses in the gastrointestinal tract of rodents.

Technology Process of Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]-

There total 5 articles about Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(2-tert-butylphenoxy)-3-isocyanatopyridine (870072-76-7) + 4-(trifluoromethoxy)aniline (461-82-5) → 1-(2-(2-(tert-butyl)phenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea (870544-59-5)

Guidance literature:

In toluene; at 80 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.ejmech.2019.01.006

Reference yield:

2-(2-(tert-butyl)phenoxy)-3-nitropyridine (861673-67-8) → 1-(2-(2-(tert-butyl)phenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea (870544-59-5)

Guidance literature:

Multi-step reaction with 3 steps

1: zinc; ammonium chloride / ethanol; ethyl acetate / 20 °C / Inert atmosphere

2: trichloromethyl chloroformate; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0 °C / Inert atmosphere

3: toluene / 1.5 h / 80 °C / Inert atmosphere

With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; ammonium chloride; zinc; trichloromethyl chloroformate; In ethanol; dichloromethane; ethyl acetate; toluene;

DOI:10.1021/jm301708u

Reference yield:

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) → 1-(2-(2-(tert-butyl)phenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea (870544-59-5)

Guidance literature:

Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

2: zinc; ammonium chloride / ethanol; ethyl acetate / 20 °C / Inert atmosphere

3: trichloromethyl chloroformate; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 0 °C / Inert atmosphere

4: toluene / 1.5 h / 80 °C / Inert atmosphere

With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; ammonium chloride; caesium carbonate; zinc; trichloromethyl chloroformate; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm301708u

upstream raw materials:

2-(2-tert-butylphenoxy)-3-isocyanatopyridine

4-(trifluoromethoxy)aniline

2-tert-Butylphenol

2-(2-(tert-butyl)phenoxy)-3-nitropyridine

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