861673-67-8Relevant articles and documents
Studies towards the development of a PET radiotracer for imaging of the P2Y1 receptors in the brain: synthesis, 18F-labeling and preliminary biological evaluation
Moldovan, Rare?-Petru,Wenzel, Barbara,Teodoro, Rodrigo,Neumann, Wilma,Dukic-Stefanovic, Sladjana,Kraus, Werner,Rong, Peijing,Deuther-Conrad, Winnie,Hey-Hawkins, Evamarie,Krügel, Ute,Brust, Peter
, p. 142 - 159 (2019/01/23)
Purine nucleotides such as ATP and ADP are important extracellular signaling molecules in almost all tissues activating various subtypes of purinoreceptors. In the brain, the P2Y1 receptor (P2Y1R) subtype mediates trophic functions l
Discovery of diarylurea P2Y1 antagonists with improved aqueous solubility
Wang, Tammy C.,Qiao, Jennifer X.,Clark, Charles G.,Jua, Ji,Price, Laura A.,Wu, Qimin,Chang, Ming,Zheng, Joanna,Huang, Christine S.,Everlof, Gerry,Schumacher, William A.,Wong, Pancras C.,Seiffert, Dietmar A.,Stewart, Anne B.,Bostwick, Jeffrey S.,Crain, Earl J.,Watson, Carol A.,Rehfuss, Robert,Wexler, Ruth R.,Lam, Patrick Y.S.
, p. 3239 - 3243 (2013/06/27)
Preclinical data suggests that P2Y1 antagonists, such as diarylurea compound 1, may provide antithrombotic efficacy similar to P2Y 12 antagonists and may have the potential of providing reduced bleeding liabilities. This manuscript d
Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y 1 antagonists
Chao, Hannguang,Turdi, Huji,Herpin, Timothy F.,Roberge, Jacques Y.,Liu, Yalei,Schnur, Dora M.,Poss, Michael A.,Rehfuss, Robert,Hua, Ji,Wu, Qimin,Price, Laura A.,Abell, Lynn M.,Schumacher, William A.,Bostwick, Jeffrey S.,Steinbacher, Thomas E.,Stewart, Anne B.,Ogletree, Martin L.,Huang, Christine S.,Chang, Ming,Cacace, Angela M.,Arcuri, Maredith J.,Celani, Deborah,Wexler, Ruth R.,Lawrence, R. Michael
, p. 1704 - 1714 (2013/04/10)
Two distinct G protein-coupled purinergic receptors, P2Y1 and P2Y12, mediate ADP-driven platelet activation. The clinical effectiveness of P2Y12 blockade is well established. Recent preclinical data suggest that P2Y1
