1-BROMO-3-ISOPROPOXYBENZENE

Base Information

• Chemical Name: 1-BROMO-3-ISOPROPOXYBENZENE
• CAS No.: 95068-01-2
• Molecular Formula: C9H11 Br O
• Molecular Weight: 215.09
• Hs Code.: 2909309090
• Mol file: 95068-01-2.mol

Synonyms:3-Bromobenzylethyl ether; m-Bromobenzyl ethyl ether

Chemical Property of 1-BROMO-3-ISOPROPOXYBENZENE

Chemical Property:

• Boiling Point: 236.7±15.0 °C (760 mmHg)
• PSA: 9.23000
• Density: 1.333±0.06 g/cm3 (20 °C, 760 mmHg)
• LogP: 2.98560

Purity/Quality:

98.5% ^*data from raw suppliers

1-bromo-3-(ethoxymethyl)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BROMO-3-ISOPROPOXYBENZENE

There total 5 articles about 1-BROMO-3-ISOPROPOXYBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2,6-dimethylpyridine (108-48-5) + (3-Bromophenyl)methanol (15852-73-0) → 1-bromo-3-(ethoxymethyl)benzene (95068-01-2)

Guidance literature:

In diethyl ether; ethanol; dichloromethane;

Reference yield: 84.0%

m-bromobenzoic aldehyde (3132-99-8) + diethoxymethylane (2031-62-1) → 1-bromo-3-(ethoxymethyl)benzene (95068-01-2)

Guidance literature:

m-bromobenzoic aldehyde; diethoxymethylane; With dicarbonyl(pentamethylcyclopentadienyl)(4-methoxyphenyl)iron; In dichloromethane; for 4h; Inert atmosphere; Irradiation; Schlenk technique;

With sodium hydroxide; In methanol; water; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tetlet.2012.07.038

Reference yield: 71.0%

ethanol (64-17-5) + meta-bromobenzyl bromide (823-78-9) → 1-bromo-3-(ethoxymethyl)benzene (95068-01-2)

Guidance literature:

With ferrous(II) sulfate heptahydrate; for 36h; Reflux;

upstream raw materials:

ethyl 3-bromobenzoate

sulfuric acid

2,6-dimethylpyridine

(3-Bromophenyl)methanol

Downstream raw materials:

2-(S)-hydroxy-3-(3-ethoxymethylphenyl)propan-1-ol trityl ether

2-(S)-hydroxy-3-(3-ethoxymethylphenyl)propan-1-ol

3-(S)-hydroxy-4-(3-ethoxymethylphenyl)-1-butyne

2-(S)-1-acetoxy-3-(3-ethoxymethylphenyl)propan-2-ol

Refernces

• 1、 Argouarch, Gilles,Grelaud, Guillaume,Roisnel, Thierry,Humphrey, Mark G.,Paul, Frédéric. "Reductive etherification of aldehydes photocatalyzed by dicarbonyl pentamethylcyclopentadienyl iron complexes". supporting information. p. 5015 - 5018. Retrieved 2012/11/07.
• 2、 -. "C4 -amide substituted compounds and their use as therapeutic agents". . . Retrieved 2008/06/13.