5-O-(DIMETHOXYTRITYL)-1,2-DIDEOXY-D-RIBOSE

Base Information

• Chemical Name: 5-O-(DIMETHOXYTRITYL)-1,2-DIDEOXY-D-RIBOSE
• CAS No.: 95049-01-7
• Molecular Formula: C26H28 O5
• Molecular Weight: 420.505
• Hs Code.: 2932190090
• Mol file: 95049-01-7.mol

Synonyms:(2R,3S)-2-[[Bis(4-methoxyphenyl)(phenyl)methoxy]methyl]tetrahydrofuran-3-ol

Chemical Property of 5-O-(DIMETHOXYTRITYL)-1,2-DIDEOXY-D-RIBOSE

Chemical Property:

• PSA: 57.15000
• LogP: 4.16210

Purity/Quality:

97% ^*data from raw suppliers

1,2-Dideoxy-5-O-DMT-D-ribose ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-O-(DIMETHOXYTRITYL)-1,2-DIDEOXY-D-RIBOSE

There total 8 articles about 5-O-(DIMETHOXYTRITYL)-1,2-DIDEOXY-D-RIBOSE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2R,3S)-2-(hydroxymethyl)tetrahydrofuran-3-ol (91547-59-0) + 4,4'-dimethoxytrityl chloride (40615-36-9) → 5-O-(4,4'-dimethoxytriphenylmethyl)-1,4-anhydro-2-deoxy-D-ribitol (95049-01-7)

Guidance literature:

With pyridine; at 20 ℃; for 12h;

DOI:10.1080/15257770.2015.1114128

Reference yield: 83.0%

5-O-(4,4'-dimethoxytrityl)-3-O-toluoyl-1,2-dideoxy-D-ribose (1332834-98-6) → 5-O-(4,4'-dimethoxytriphenylmethyl)-1,4-anhydro-2-deoxy-D-ribitol (95049-01-7)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 2h; Reflux;

DOI:10.1039/c1ob05739a

Reference yield:

di-O-toluoyl-1,2-dideoxy-D-ribose (100269-88-3) → 5-O-(4,4'-dimethoxytriphenylmethyl)-1,4-anhydro-2-deoxy-D-ribitol (95049-01-7)

Guidance literature:

Multi-step reaction with 3 steps

1: pseudomonas cepacia lipase immobilised on ceramic / 1,4-dioxane / 2 h / 50 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction

2: pyridine / 3 h / 20 °C

3: sodium methylate / methanol / 2 h / 20 °C / Reflux

With pyridine; sodium methylate; In 1,4-dioxane; methanol;

DOI:10.1039/c1ob05739a

upstream raw materials:

(2R,3S)-2-(hydroxymethyl)tetrahydrofuran-3-ol

4,4'-dimethoxytrityl chloride

5-O-(4,4'-dimethoxytrityl)-3-O-toluoyl-1,2-dideoxy-D-ribose

3-O-toluoyl-1,2-dideoxy-D-ribose

Downstream raw materials:

(2R,3S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-methoxytetrahydrofuran

triethylammonium-[1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-D-ribofuranose-3-O-hydrogenphosphonate]