2-[1-(2-trifluoromethylbenzylidene)acetonyl]-2-oxo-1,3,2-dioxaphosphorinane

Base Information

• Chemical Name: 2-[1-(2-trifluoromethylbenzylidene)acetonyl]-2-oxo-1,3,2-dioxaphosphorinane
• CAS No.: 115578-81-9
• Molecular Formula: C₁₄H₁₄F₃O₄P
• Molecular Weight: 334.232
• Mol file: 115578-81-9.mol

Synonyms:2-[1-(2-trifluoromethylbenzylidene)acetonyl]-2-oxo-1,3,2-dioxaphosphorinane

Chemical Property of 2-[1-(2-trifluoromethylbenzylidene)acetonyl]-2-oxo-1,3,2-dioxaphosphorinane

Chemical Property:

Purity/Quality:

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Technology Process of 2-[1-(2-trifluoromethylbenzylidene)acetonyl]-2-oxo-1,3,2-dioxaphosphorinane

There total 1 articles about 2-[1-(2-trifluoromethylbenzylidene)acetonyl]-2-oxo-1,3,2-dioxaphosphorinane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Trifluoromethylbenzaldehyde (447-61-0) + 2-acetonyl-2-oxo-1,3,2-dioxaphosphorinane (115579-08-3) → (Z)-3-(2-Oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-4-(2-trifluoromethyl-phenyl)-but-3-en-2-one (115579-31-2) + 2-[1-(2-trifluoromethylbenzylidene)acetonyl]-2-oxo-1,3,2-dioxaphosphorinane (115578-81-9)

Guidance literature:

piperdinium acetate; In benzene; Yield given. Yields of byproduct given; Heating;

DOI:10.1248/cpb.35.4144

Reference yield:

methyl 3-amino-4-dimethoxycrotonate + 2-[1-(2-trifluoromethylbenzylidene)acetonyl]-2-oxo-1,3,2-dioxaphosphorinane (115578-81-9) → methyl 2-dimethoxymethyl-6-methyl-5-(2-oxo-1,3,2-dioxaphosphorinan-2-yl)-4-(2-trifluoromethylphenyl)-1,4-dihydropyridine-3-carboxylate (115569-94-3)

Guidance literature:

In ethanol;

upstream raw materials:

2-Trifluoromethylbenzaldehyde

2-acetonyl-2-oxo-1,3,2-dioxaphosphorinane

Downstream raw materials:

methyl 2-dimethoxymethyl-6-methyl-5-(2-oxo-1,3,2-dioxaphosphorinan-2-yl)-4-(2-trifluoromethylphenyl)-1,4-dihydropyridine-3-carboxylate