2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide

Base Information

Chemical Name:2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide
CAS No.:1350713-47-1
Molecular Formula:C₂₂H₃₀N₄O₃Si
Molecular Weight:426.591
Hs Code.:

Synonyms:2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide

Suppliers and Price of 2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide

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Chemical Property of 2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide

There total 9 articles about 2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1334675-23-8
2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

: 75-31-0
isopropylamine

: 1350713-47-1
2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide

Guidance literature:: With dmap; In dichloromethane; at 20 ℃;

Reference yield:

: 1350713-64-2
2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide

: 108-95-2,27073-41-2
phenol

: 1350713-47-1
2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide

Guidance literature:: With potassium phosphate; palladium diacetate; 2'-(di-tert-butylphosphanyl)-N,N-dimethyl-[1,1'-biphenyl]-2-amine; In toluene; at 140 ℃; for 18h; Inert atmosphere; Sealed tube;
DOI:10.1016/j.bmcl.2013.03.015

Reference yield:

: 1185428-34-5
2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo-[2,3-b]pyrazine-7-carbaldehyde

: 1350713-47-1
2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate / palladium diacetate / toluene / 150 °C / Inert atmosphere; Sealed tube

2: Jones reagent / acetone / 2 h / 0 - 20 °C

3: dmap / dichloromethane / 20 °C

With dmap; potassium phosphate; Jones reagent; palladium diacetate; In dichloromethane; acetone; toluene;