2-[4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy] benzyloxy]nicotinonitrile

Base Information

• Chemical Name: 2-[4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy] benzyloxy]nicotinonitrile
• CAS No.: 441357-44-4
• Molecular Formula: C₂₈H₂₁N₃O₃
• Molecular Weight: 447.493
• Mol file: 441357-44-4.mol

Synonyms:2-[4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzyloxy]nicotinonitrile

Chemical Property of 2-[4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy] benzyloxy]nicotinonitrile

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy] benzyloxy]nicotinonitrile

There total 1 articles about 2-[4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy] benzyloxy]nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-chloro-3-pyridinecarbonitrile (6602-54-6) + 4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzyl alcohol (441357-43-3) → 2-[4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzyloxy]nicotinonitrile (441357-44-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 30 ℃; for 2h;

Reference yield:

2-[4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzyloxy]nicotinonitrile (441357-44-4) → C28H22N2O4 (441357-45-5)

Guidance literature:

2-[4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzyloxy]nicotinonitrile; With diisobutylaluminium hydride; In hexane; toluene; at -78 - 30 ℃; for 1h;

With ammonium chloride; In hexane; water; toluene; at 1 - 30 ℃; for 0.5h;

upstream raw materials:

2-chloro-3-pyridinecarbonitrile

4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzyl alcohol

Downstream raw materials:

C₂₈H₂₂N₂O₄