1-methoxycarbonylmethyl-1-(4-nitrobenzenesulfonyl)-4,4-bis(tert-butoxycarbonylmethyl)-1,4-diazabutane

Base Information

Chemical Name:1-methoxycarbonylmethyl-1-(4-nitrobenzenesulfonyl)-4,4-bis(tert-butoxycarbonylmethyl)-1,4-diazabutane
CAS No.:1566605-91-1
Molecular Formula:C₂₃H₃₅N₃O₁₀S
Molecular Weight:545.611
Hs Code.:

Synonyms:1-methoxycarbonylmethyl-1-(4-nitrobenzenesulfonyl)-4,4-bis(tert-butoxycarbonylmethyl)-1,4-diazabutane

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Chemical Property of 1-methoxycarbonylmethyl-1-(4-nitrobenzenesulfonyl)-4,4-bis(tert-butoxycarbonylmethyl)-1,4-diazabutane

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Technology Process of 1-methoxycarbonylmethyl-1-(4-nitrobenzenesulfonyl)-4,4-bis(tert-butoxycarbonylmethyl)-1,4-diazabutane

There total 4 articles about 1-methoxycarbonylmethyl-1-(4-nitrobenzenesulfonyl)-4,4-bis(tert-butoxycarbonylmethyl)-1,4-diazabutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 4-benzyloxycarbonylmethyl-1,1,7,7-tetra(carboxymethyl)-1,4,7-triazaheptane trihydrochloride

: methyl 2-[(4-nitrophenyl)sulfonylamino]acetate

: 1566605-91-1
1-methoxycarbonylmethyl-1-(4-nitrobenzenesulfonyl)-4,4-bis(tert-butoxycarbonylmethyl)-1,4-diazabutane

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 6h;
DOI:10.1021/ol500022n

Reference yield:

: 54769-58-3
1H-benzo[d][1,2,3]triazol-1-yl 4-nitrobenzenesulfonate

: 1566605-91-1
1-methoxycarbonylmethyl-1-(4-nitrobenzenesulfonyl)-4,4-bis(tert-butoxycarbonylmethyl)-1,4-diazabutane

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; dichloromethane / 16 h / 20 °C / Inert atmosphere

2: potassium carbonate / acetonitrile / 6 h / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol500022n

Reference yield:

: 178552-82-4
4-benzyloxycarbonylmethyl-1,1,7,7-tetra(tertbutyloxycarbonylmethyl)-1,4,7-triazaheptane

: 1566605-91-1
1-methoxycarbonylmethyl-1-(4-nitrobenzenesulfonyl)-4,4-bis(tert-butoxycarbonylmethyl)-1,4-diazabutane

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 3 h / 80 °C

2: potassium carbonate / acetonitrile / 6 h / 20 °C

With hydrogenchloride; potassium carbonate; In 1,4-dioxane; acetonitrile;
DOI:10.1021/ol500022n