(S)-methyl 3-(5-chloropyridin-2-yl)-3-amino-3-(3-fluoro-5-(trifluoromethyl)phenyl)propanoate

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Chemical Name:(S)-methyl 3-(5-chloropyridin-2-yl)-3-amino-3-(3-fluoro-5-(trifluoromethyl)phenyl)propanoate
CAS No.:939425-80-6
Molecular Formula:C₁₆H₁₃ClF₄N₂O₂
Molecular Weight:376.738
Hs Code.:

Synonyms:(S)-methyl 3-(5-chloropyridin-2-yl)-3-amino-3-(3-fluoro-5-(trifluoromethyl)phenyl)propanoate

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Chemical Property of (S)-methyl 3-(5-chloropyridin-2-yl)-3-amino-3-(3-fluoro-5-(trifluoromethyl)phenyl)propanoate

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Technology Process of (S)-methyl 3-(5-chloropyridin-2-yl)-3-amino-3-(3-fluoro-5-(trifluoromethyl)phenyl)propanoate

There total 5 articles about (S)-methyl 3-(5-chloropyridin-2-yl)-3-amino-3-(3-fluoro-5-(trifluoromethyl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 939039-35-7
(S)-methyl 3-(5-chloropyridin-2-yl)-3-((R)-1,1-dimethylethylsulfinamino)-3-(3-fluoro-5-(trifluoromethyl)phenyl)propanoate

: 939425-80-6
(S)-methyl 3-(5-chloropyridin-2-yl)-3-amino-3-(3-fluoro-5-(trifluoromethyl)phenyl)propanoate

Guidance literature:: (S)-methyl 3-(5-chloropyridin-2-yl)-3-((R)-1,1-dimethylethylsulfinamino)-3-(3-fluoro-5-(trifluoromethyl)phenyl)propanoate; With hydrogenchloride; methanol; In 1,4-dioxane; at 20 ℃; for 0.5h;

With sodium hydroxide; In 1,4-dioxane; water;

Reference yield:

: 89809-64-3
2-cyano-5-chloropyridine

: 939425-80-6
(S)-methyl 3-(5-chloropyridin-2-yl)-3-amino-3-(3-fluoro-5-(trifluoromethyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / diethyl ether / 0.5 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / 14 h / 75 °C

3.1: lithium diisopropyl amide / tetrahydrofuran; diethyl ether; n-heptane / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h

4.2: pH 10

With hydrogenchloride; titanium(IV) tetraethanolate; n-butyllithium; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; n-heptane;
DOI:10.1016/j.tet.2012.01.050

Reference yield:

: 939039-29-9
(5-chloropyridin-2-yl)(3-fluoro-5-(trifluoromethyl)phenyl)methanone

: 939425-80-6
(S)-methyl 3-(5-chloropyridin-2-yl)-3-amino-3-(3-fluoro-5-(trifluoromethyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 14 h / 75 °C

2.1: lithium diisopropyl amide / tetrahydrofuran; diethyl ether; n-heptane / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h

3.2: pH 10

With hydrogenchloride; titanium(IV) tetraethanolate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; n-heptane;
DOI:10.1016/j.tet.2012.01.050