ethyl 2-methyl-4-(naphth-1-yl)-4-(1-tosyl-1H-indol-3-yl)but-2(Z)-enoate

Base Information

• Chemical Name: ethyl 2-methyl-4-(naphth-1-yl)-4-(1-tosyl-1H-indol-3-yl)but-2(Z)-enoate
• CAS No.: 1280135-90-1
• Molecular Formula: C₃₂H₂₉NO₄S
• Molecular Weight: 523.653
• Mol file: 1280135-90-1.mol

Synonyms:ethyl 2-methyl-4-(naphth-1-yl)-4-(1-tosyl-1H-indol-3-yl)but-2(Z)-enoate

Chemical Property of ethyl 2-methyl-4-(naphth-1-yl)-4-(1-tosyl-1H-indol-3-yl)but-2(Z)-enoate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl 2-methyl-4-(naphth-1-yl)-4-(1-tosyl-1H-indol-3-yl)but-2(Z)-enoate

There total 2 articles about ethyl 2-methyl-4-(naphth-1-yl)-4-(1-tosyl-1H-indol-3-yl)but-2(Z)-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-(p-toluenesulfonyl)-1H-indole (31271-90-6) + ethyl 2-methyl-4-(α-naphthyl)buta-2,3-dienoate (189625-96-5) → ethyl 2-methyl-4-(naphth-1-yl)-4-(1-tosyl-1H-indol-3-yl)but-2(Z)-enoate (1280135-90-1)

Guidance literature:

With trifluoroacetic acid; at 5 ℃; for 2.5h; optical yield given as %de; regioselective reaction;

DOI:10.1002/ejoc.201001661

Reference yield: 55.0%

1-(p-toluenesulfonyl)-1H-indole (31271-90-6) + ethyl 2-methyl-4-(α-naphthyl)buta-2,3-dienoate (189625-96-5) → ethyl 2-methyl-4-(naphth-1-yl)-4-(1-tosyl-1H-indol-3-yl)but-2(Z)-enoate (1280135-90-1) + ethyl 2-methyl-4-(naphth-1-yl)-4-(1-tosyl-1H-indol-3-yl)but-2(E)-enoate (1280135-99-0)

Guidance literature:

With trifluoroacetic acid; at 80 ℃; for 3h; optical yield given as %de; regioselective reaction;

DOI:10.1002/ejoc.201001661

upstream raw materials:

1-(p-toluenesulfonyl)-1H-indole

ethyl 2-methyl-4-(α-naphthyl)buta-2,3-dienoate