3-(4-methylpiperidine-4-carboxamido)phenyl N,N-dimethylcarbamate hydrochloride

Base Information

• Chemical Name: 3-(4-methylpiperidine-4-carboxamido)phenyl N,N-dimethylcarbamate hydrochloride
• CAS No.: 1192189-47-1
• Molecular Formula: C₁₆H₂₃N₃O₃*ClH
• Molecular Weight: 341.838

Synonyms:3-(4-methylpiperidine-4-carboxamido)phenyl N,N-dimethylcarbamate hydrochloride

Chemical Property of 3-(4-methylpiperidine-4-carboxamido)phenyl N,N-dimethylcarbamate hydrochloride

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Technology Process of 3-(4-methylpiperidine-4-carboxamido)phenyl N,N-dimethylcarbamate hydrochloride

There total 2 articles about 3-(4-methylpiperidine-4-carboxamido)phenyl N,N-dimethylcarbamate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Dimethylcarbaminsaeure-3-aminophenylester (19962-04-0) → 3-(4-methylpiperidine-4-carboxamido)phenyl N,N-dimethylcarbamate hydrochloride (1192189-47-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.75 h / Inert atmosphere; Sealed tube; High pressure

1.2: 18 h / 85 °C / Inert atmosphere; Sealed tube; High pressure

2.1: hydrogenchloride; methanol / 1,4-dioxane / 3 h / 40 °C / Inert atmosphere

With hydrogenchloride; methanol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane;

DOI:10.1021/ml500367g

Reference yield:

1-(tert-butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid (189321-63-9) → 3-(4-methylpiperidine-4-carboxamido)phenyl N,N-dimethylcarbamate hydrochloride (1192189-47-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.75 h / Inert atmosphere; Sealed tube; High pressure

1.2: 18 h / 85 °C / Inert atmosphere; Sealed tube; High pressure

2.1: hydrogenchloride; methanol / 1,4-dioxane / 3 h / 40 °C / Inert atmosphere

With hydrogenchloride; methanol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane;

DOI:10.1021/ml500367g

Reference yield: 53.0%

3-(4-methylpiperidine-4-carboxamido)phenyl N,N-dimethylcarbamate hydrochloride (1192189-47-1) + 4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine (1618-36-6) → 3-(4-methyl-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl N,N-dimethylcarbamate (1192189-45-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 100 ℃; for 18h;

upstream raw materials:

Dimethylcarbaminsaeure-3-aminophenylester

1-(tert-butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid

Downstream raw materials:

3-(4-methyl-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido)phenyl N,N-dimethylcarbamate

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