189321-63-9

Basic information

• Product Name: 1-Boc-4-methylpiperidine-4-carboxylic acid
• Synonyms: N-BOC-4-METHYL ISONIPECOTIC ACID;N-BOC-4-METHYL-4-METHYLPIPERIDINECARBOXYLIC ACID;N-BOC-4-METHYL-4-PIPERIDINECARBOXYLIC ACID;CHEMBRDG-BB 4002933;4-METHYL-4-CARBOXY-1-N-BOC-PIPERIDINE;4-METHYL-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER;1-BOC-4-METHYL-PIPERIDINE-4-CARBOXYLIC ACID;1-Boc-4-methyl-4-piperidinecarboxylic Acid
• CAS NO: 189321-63-9
• Molecular Formula: C₁₂H₂₁NO₄
• Molecular Weight: 243.3
• Product Categories: Amino Acids and Derivatives;Heterocycles;API intermediates;Pyridines
• Mol File: 189321-63-9.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 354.3 °C at 760 mmHg
• Flash Point: 168.1 °C
• Appearance: /
• Density: 1.129 g/cm³
• Vapor Pressure: 5.65E-06mmHg at 25°C
• Refractive Index: 1.489
• Storage Temp.: 2-8°C
• PKA: 4.69±0.20(Predicted)
• CAS DataBase Reference: 1-Boc-4-methylpiperidine-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-4-methylpiperidine-4-carboxylic acid(189321-63-9)
• EPA Substance Registry System: 1-Boc-4-methylpiperidine-4-carboxylic acid(189321-63-9)

Safety Data

• RIDADR: UN2811
• HazardClass: IRRITANT
• Hazardous Substances Data: 189321-63-9(Hazardous Substances Data)

Usage

General Description

"1-Boc-4-methylpiperidine-4-carboxylic acid" is a complex organic chemical compound often used in the scientific research and medicinal chemistry for the synthesis of various pharmaceutical agents. Its structure comprises a core piperidine ring, which is a common feature in many pharmaceutical preparations because of its ability to bind various targets, further modified by carboxylic acid and Boc (tert-butyloxycarbonyl) groups. The Boc group is particularly useful as it is a protective group typically used in organic synthesis to temporarily shield amine groups from unwanted reactions. the carboxylic acid moiety offers the potential for subsequent modifications, increasing the utility of this chemical in synthesizing diverse bioactive molecules. As such, 1-Boc-4-methylpiperidine-4-carboxylic acid plays a valuable role in drug design and synthesis.

InChI:InChI=1/C12H21NO4/c1-11(2,3)17-10(16)13-7-5-12(4,6-8-13)9(14)15/h5-8H2,1-4H3,(H,14,15)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 162648-32-0 4-methylpiperidine-4-carboxylic acid 
• 67-56-1 methanol 
• 189442-87-3 ethyl tert-butyl 4-methylpiperidine-1,4-dicarboxylate 
• 236406-21-6 4-(hydroxymethyl)-4-methylpiperidine-1-carboxylic acid tert-butyl ester 
• 177990-33-9 4-Benzyloxycarbonyl-1-tert-butoxycarbonylpiperidine 
• 1126-09-6 4-carbethoxypiperidine 
• 498-94-2 isonipecotic acid 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 124443-68-1 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate 
• 296240-48-7 benzyl 1-tert-butoxycarbonyl-4-methyl-4-piperidinecarboxylate 
• 724790-59-4 4-methyl-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-methyl ester 
• 7664-93-9 sulfuric acid 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 901308-97-2 2-(2-tert-Butylphenoxy)-N-(5-(4-methylpiperidin-4-yl)-1,3,4-thiadiazol-2-yl)pyridin-3-amine 
• 343788-67-0 4-carbamoyl-4-methylpiperidine-1-carboxylic acid tert-butyl ester 
• 236406-15-8 (4-methyl-piperidin-4-yl)-carbamic acid benzyl ester 
• 1421928-79-1 ethyl 2-(4-(((benzyloxy)carbonyl)amino)-4-methylpiperidin-1-yl)acetate 
• 1067914-49-1 benzyl 1-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-4-methylpiperidin-4-ylcarbamate 
• 1067915-26-7 benzyl 1-(6-fluoro-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-4-methylpiperidin-4-ylcarbamate 
• 1067915-27-8 benzyl 1-(5-fluoro-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-4-methylpiperidin-4-ylcarbamate 
• 186595-79-9 4-(4-fluorobenzoyl)-4-methyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester 
• 236406-14-7 1,1-dimethylethyl 4-methyl-4-({[(phenylmethyl)oxy]carbonyl}amino)-1-piperidinecarboxylate 
• 225240-67-5 1-acetyl-4-methylpiperidine-4-carboxylic acid 

Relevant articles and documents

Oxidation of Primary Alcohols and Aldehydes to Carboxylic Acids via Hydrogen Atom Transfer

The oxidation of primary alcohols and aldehydes to the corresponding carboxylic acids is a fundamental reaction in organic synthesis. In this paper, we report a new chemoselective process for the oxidation of primary alcohols and aldehydes. This metal-free reaction features a new oxidant, an easy to handle procedure, high isolated yields, and good to excellent functional group tolerance even in the presence of vulnerable secondary alcohols and tert-butanesulfinamides.

Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels

Transient receptor potential canonical 3/6/7 (TRPC3/6/7) are highly homologous receptor-operated nonselective cation channels. Despite their physiological significance, very few selective and potent agonists are available for functional examination of these channels. Using a cell-based high throughput screening approach, a lead compound with the pyrazolopyrimidine skeleton was identified as a TRPC6 agonist. Synthetic schemes for the lead and its analogues were established, and structural-activity relationship studies were carried out. A series of potent and direct agonists of TRPC3/6/7 channels were identified, and among them, 4m-4p have a potency order of TRPC3 > C7 > C6, with 4n being the most potent with an EC50 of 20 nM on TRPC3. Importantly, these compounds exhibited no stimulatory activity on related TRP channels. The potent and selective compounds described here should be suitable for evaluation of the roles of TRPC channels in the physiology and pathogenesis of diseases, including glomerulosclerosis and cancer.

A pyrazolo [1,5-a] pyrimidine derivative and its anti-tumor use

The present invention relates to a pyrazolo[1,5-a]pyrimidine derivative of general formula 1 and a pharmaceutically acceptable salt thereof. The present invention also relates to use of compounds of formula 1 in the preparation of an anti-tumor medicament.