189321-63-9

Usage

Uses

Used in Pharmaceutical Industry:
1-Boc-4-methylpiperidine-4-carboxylic acid is used as a building block for the synthesis of various pharmaceutical agents. Its core piperidine ring and carboxylic acid group enable the creation of diverse bioactive molecules, contributing to the development of new drugs.
Used in Medicinal Chemistry Research:
1-Boc-4-methylpiperidine-4-carboxylic acid is used as a research compound for exploring its potential in medicinal chemistry. The Boc group's protective properties and the carboxylic acid's reactivity make it an ideal candidate for studying the synthesis of complex molecules and their interactions with biological targets.
Used in Organic Synthesis:
1-Boc-4-methylpiperidine-4-carboxylic acid is used as a synthetic intermediate in organic synthesis. The Boc group provides a means to protect amine groups during reactions, while the carboxylic acid group offers opportunities for further functionalization, making it a valuable component in the preparation of a broad spectrum of organic compounds.

InChI:InChI=1/C12H21NO4/c1-11(2,3)17-10(16)13-7-5-12(4,6-8-13)9(14)15/h5-8H2,1-4H3,(H,14,15)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 162648-32-0 4-methylpiperidine-4-carboxylic acid 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 
• 189442-87-3 ethyl tert-butyl 4-methylpiperidine-1,4-dicarboxylate 
• 7664-93-9 sulfuric acid 
• 724790-59-4 4-methyl-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-methyl ester 
• 296240-48-7 benzyl 1-tert-butoxycarbonyl-4-methyl-4-piperidinecarboxylate 
• 124443-68-1 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate 
• 177990-33-9 4-Benzyloxycarbonyl-1-tert-butoxycarbonylpiperidine 
• 236406-21-6 4-(hydroxymethyl)-4-methylpiperidine-1-carboxylic acid tert-butyl ester 
• 1126-09-6 4-carbethoxypiperidine 
• 498-94-2 isonipecotic acid 

Downstream Products

• 236406-14-7 1,1-dimethylethyl 4-methyl-4-({[(phenylmethyl)oxy]carbonyl}amino)-1-piperidinecarboxylate 
• 901308-97-2 2-(2-tert-Butylphenoxy)-N-(5-(4-methylpiperidin-4-yl)-1,3,4-thiadiazol-2-yl)pyridin-3-amine 
• 186595-79-9 4-(4-fluorobenzoyl)-4-methyl-1-piperidinecarboxylic acid 1,1-dimethylethyl ester 
• 236406-15-8 (4-methyl-piperidin-4-yl)-carbamic acid benzyl ester 
• 1018990-46-9 t-butyl 4-(3,5-bis(trifluoromethyl)benzylcarbamoyl)-4-methylpiperidine-1-carboxylate 
• 343788-67-0 4-carbamoyl-4-methylpiperidine-1-carboxylic acid tert-butyl ester 
• 162648-32-0 4-methylpiperidine-4-carboxylic acid 
• 1421928-79-1 ethyl 2-(4-(((benzyloxy)carbonyl)amino)-4-methylpiperidin-1-yl)acetate 
• 1431972-47-2 tert-butyl 4-(3-(4-bromophenyl)-3-o-tolylpropanoyl)piperidine-1-carboxylate 
• 1431972-48-3 3-(4-bromophenyl)-1-(piperidin-4-yl)-3-o-tolylpropan-1-one 
• 1431972-49-4 1-(1-acetylpiperidin-4-yl)-3-(4-bromophenyl)-3-o-tolylpropan-1-one 
• 1067914-49-1 benzyl 1-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-4-methylpiperidin-4-ylcarbamate 
• 1067915-26-7 benzyl 1-(6-fluoro-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-4-methylpiperidin-4-ylcarbamate 
• 1067915-27-8 benzyl 1-(5-fluoro-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinolin-8-yl)-4-methylpiperidin-4-ylcarbamate 

Relevant academic research and scientific papers

2,3-DIHYDRO-1H-PYRROLIZINE-7-FORMAMIDE DERIVATIVE AND APPLICATION THEREOF

The present application relates to a 2,3-dihydro-1H-pyrrolizine-7-formamide derivative as a nucleoprotein inhibitor and a use in preparation of a drug for treating HBV related diseases. The present application specifically relates to a compound represented by formula (II), and isomers or pharmaceutically acceptable salts thereof.

Oxidation of Primary Alcohols and Aldehydes to Carboxylic Acids via Hydrogen Atom Transfer

The oxidation of primary alcohols and aldehydes to the corresponding carboxylic acids is a fundamental reaction in organic synthesis. In this paper, we report a new chemoselective process for the oxidation of primary alcohols and aldehydes. This metal-free reaction features a new oxidant, an easy to handle procedure, high isolated yields, and good to excellent functional group tolerance even in the presence of vulnerable secondary alcohols and tert-butanesulfinamides.

Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels

Transient receptor potential canonical 3/6/7 (TRPC3/6/7) are highly homologous receptor-operated nonselective cation channels. Despite their physiological significance, very few selective and potent agonists are available for functional examination of these channels. Using a cell-based high throughput screening approach, a lead compound with the pyrazolopyrimidine skeleton was identified as a TRPC6 agonist. Synthetic schemes for the lead and its analogues were established, and structural-activity relationship studies were carried out. A series of potent and direct agonists of TRPC3/6/7 channels were identified, and among them, 4m-4p have a potency order of TRPC3 > C7 > C6, with 4n being the most potent with an EC50 of 20 nM on TRPC3. Importantly, these compounds exhibited no stimulatory activity on related TRP channels. The potent and selective compounds described here should be suitable for evaluation of the roles of TRPC channels in the physiology and pathogenesis of diseases, including glomerulosclerosis and cancer.

PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVE AND USE OF ANTI-TUMOR THEREOF

The present invention relates to a pyrazolo[1,5-a]pyrimidine derivative of general formula 1 and a pharmaceutically acceptable salt thereof. The present invention also relates to use of compounds of formula 1 in the preparation of an anti-tumor medicament.

A pyrazolo [1,5-a] pyrimidine derivative and its anti-tumor use

The present invention relates to a pyrazolo[1,5-a]pyrimidine derivative of general formula 1 and a pharmaceutically acceptable salt thereof. The present invention also relates to use of compounds of formula 1 in the preparation of an anti-tumor medicament.

COMPOUNDS AND METHODS

The present invention relates to novel retinoid-related orphan receptor gamma (RORy) modulators and their use in the treatment of diseases mediated by RORy.

AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS

The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment

UREIDE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES

This invention relates to a pharmaceutical comprising, as an active ingredient, a ureide derivative represented by formula: or a pharmaceutically acceptable salt thereof. The ureide derivative or a pharmaceutically acceptable salt thereof according to the present invention is useful for relieving pain and treating or preventing neuropathic pain.

IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS

Compounds of Formula (I) in which A, B, R1, R1a, R2, R3, R4, R5, R6, R7 and R8 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by class 3 and class 5 receptor tyrosine kinases. Particular compounds of this invention have also been found to be inhibitors of Pim-1