rac-(1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-4-(1-hydroxymethyl-3-oxo-3-piperidin-1-yl-propyl)-[1,4] diazepan-5-one)

Base Information

Chemical Name:rac-(1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-4-(1-hydroxymethyl-3-oxo-3-piperidin-1-yl-propyl)-[1,4] diazepan-5-one)
CAS No.:1290048-97-3
Molecular Formula:C₂₃H₂₉Cl₂N₃O₄
Molecular Weight:482.407
Hs Code.:

Synonyms:rac-(1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-4-(1-hydroxymethyl-3-oxo-3-piperidin-1-yl-propyl)-[1,4] diazepan-5-one)

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Chemical Property of rac-(1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-4-(1-hydroxymethyl-3-oxo-3-piperidin-1-yl-propyl)-[1,4] diazepan-5-one)

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Technology Process of rac-(1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-4-(1-hydroxymethyl-3-oxo-3-piperidin-1-yl-propyl)-[1,4] diazepan-5-one)

There total 8 articles about rac-(1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-4-(1-hydroxymethyl-3-oxo-3-piperidin-1-yl-propyl)-[1,4] diazepan-5-one) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1290048-98-4
rac-2-{4-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-7-oxo-[1,4]diazepan-1-yl}-4-oxo-4-piperidin-1-yl-butyric acid methyl ester

: 1290048-97-3
rac-(1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-4-(1-hydroxymethyl-3-oxo-3-piperidin-1-yl-propyl)-[1,4] diazepan-5-one)

Guidance literature:: With lithium borohydride; In ethanol; at 20 ℃; for 48h;

Reference yield:

: 34376-54-0
[1,4]diazepan-5-one

: 1290048-97-3
rac-(1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-4-(1-hydroxymethyl-3-oxo-3-piperidin-1-yl-propyl)-[1,4] diazepan-5-one)

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C

1.2: 0 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C

2.2: -78 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

3.2: 5 h / -78 °C

4.1: hydrogenchloride; water / 1,4-dioxane / 6 - 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C

6.1: lithium borohydride / ethanol / 48 h / 0 - 20 °C

With hydrogenchloride; lithium borohydride; oxalyl dichloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hexamethyldisilazane; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;

Reference yield:

: 7312-27-8
3,4-Dichlorocinnamic acid

: 1290048-97-3
rac-(1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-4-(1-hydroxymethyl-3-oxo-3-piperidin-1-yl-propyl)-[1,4] diazepan-5-one)

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C

1.2: 0 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C

2.2: -78 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

3.2: 5 h / -78 °C

4.1: hydrogenchloride; water / 1,4-dioxane / 6 - 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 °C

6.1: lithium borohydride / ethanol / 48 h / 0 - 20 °C

With hydrogenchloride; lithium borohydride; oxalyl dichloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hexamethyldisilazane; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;