(2S,3S,4S,5R,6R)-3-Acetoxy-5-benzoyloxy-4-(4-oxo-pentanoyloxy)-6-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

Base Information

Chemical Name:(2S,3S,4S,5R,6R)-3-Acetoxy-5-benzoyloxy-4-(4-oxo-pentanoyloxy)-6-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester
CAS No.:181718-67-2
Molecular Formula:C₂₃H₂₄Cl₃NO₁₁
Molecular Weight:596.803
Hs Code.:

(2S,3S,4S,5R,6R)-3-Acetoxy-5-benzoyloxy-4-(4-oxo-pentanoyloxy)-6-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

Synonyms:(2S,3S,4S,5R,6R)-3-Acetoxy-5-benzoyloxy-4-(4-oxo-pentanoyloxy)-6-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

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Chemical Property of (2S,3S,4S,5R,6R)-3-Acetoxy-5-benzoyloxy-4-(4-oxo-pentanoyloxy)-6-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

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Technology Process of (2S,3S,4S,5R,6R)-3-Acetoxy-5-benzoyloxy-4-(4-oxo-pentanoyloxy)-6-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

There total 8 articles about (2S,3S,4S,5R,6R)-3-Acetoxy-5-benzoyloxy-4-(4-oxo-pentanoyloxy)-6-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 545-06-2
trichloroacetonitrile

: (2S,3S,4S,5R)-3-Acetoxy-5-benzoyloxy-6-hydroxy-4-(4-oxo-pentanoyloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

: 181718-67-2
(2S,3S,4S,5R,6R)-3-Acetoxy-5-benzoyloxy-4-(4-oxo-pentanoyloxy)-6-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1080/07328309608005705

Reference yield:

: 40608-06-8
levulinic anhydride

: 181718-67-2
(2S,3S,4S,5R,6R)-3-Acetoxy-5-benzoyloxy-4-(4-oxo-pentanoyloxy)-6-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / pyridine, DMAP / Ambient temperature

2: TFA / CH₂Cl₂ / 2 h / Ambient temperature

3: 95 percent / DBU / CH₂Cl₂ / 2 h / 0 °C

With pyridine; dmap; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In dichloromethane;
DOI:10.1080/07328309608005705

Reference yield:

: 93-97-0
benzoic acid anhydride

: 181718-67-2
(2S,3S,4S,5R,6R)-3-Acetoxy-5-benzoyloxy-4-(4-oxo-pentanoyloxy)-6-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) (n-Bu₂)SnO / 1.) toluene, 100 deg C, 15 h, 2.) 100 deg C, 10 min

2: 76 percent / pyridine, DMAP / Ambient temperature

3: TFA / CH₂Cl₂ / 2 h / Ambient temperature

4: 95 percent / DBU / CH₂Cl₂ / 2 h / 0 °C

With pyridine; dmap; di(n-butyl)tin oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In dichloromethane;
DOI:10.1080/07328309608005705