3-[2-Phenyl-1-((S)-toluene-4-sulfinyl)-eth-(E)-ylidene]-1-oxa-4-aza-spiro[4.5]decane

Base Information

Chemical Name:3-[2-Phenyl-1-((S)-toluene-4-sulfinyl)-eth-(E)-ylidene]-1-oxa-4-aza-spiro[4.5]decane
CAS No.:812665-19-3
Molecular Formula:C₂₃H₂₇NO₂S
Molecular Weight:381.539
Hs Code.:

Synonyms:3-[2-Phenyl-1-((S)-toluene-4-sulfinyl)-eth-(E)-ylidene]-1-oxa-4-aza-spiro[4.5]decane

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Chemical Property of 3-[2-Phenyl-1-((S)-toluene-4-sulfinyl)-eth-(E)-ylidene]-1-oxa-4-aza-spiro[4.5]decane

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Technology Process of 3-[2-Phenyl-1-((S)-toluene-4-sulfinyl)-eth-(E)-ylidene]-1-oxa-4-aza-spiro[4.5]decane

There total 1 articles about 3-[2-Phenyl-1-((S)-toluene-4-sulfinyl)-eth-(E)-ylidene]-1-oxa-4-aza-spiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 100-39-0
benzyl bromide

: 146860-26-6
(+)-(R_S)-3-{[(4-methylphenyl)sulfinyl]methyl}-1-oxa-4-azaspiro[4.5]dec-3-ene

: 812665-19-3
3-[2-Phenyl-1-((S)-toluene-4-sulfinyl)-eth-(E)-ylidene]-1-oxa-4-aza-spiro[4.5]decane

Guidance literature:: (+)-(R_S)-3-{[(4-methylphenyl)sulfinyl]methyl}-1-oxa-4-azaspiro[4.5]dec-3-ene; With n-butyllithium; In tetrahydrofuran; hexane; at -50 ℃; for 0.666667h;

benzyl bromide; In tetrahydrofuran; at -50 - 22 ℃;
DOI:10.1016/j.tetasy.2004.09.010

Reference yield:

: 812665-19-3
3-[2-Phenyl-1-((S)-toluene-4-sulfinyl)-eth-(E)-ylidene]-1-oxa-4-aza-spiro[4.5]decane

: (R_S,2R,3R)-2-(cyclohexylamine)-3-[(4-methylphenyl)sulfinyl]-4-phenylbutan-1-ol

: (R_S,2R,3S)-2-(cyclohexylamine)-3-[(4-methylphenyl)sulfinyl]-4-phenylbutan-1-ol

Guidance literature:: With diisobutylaluminium hydride; zinc(II) chloride; In tetrahydrofuran; toluene; at -78 - 23 ℃; for 15.5h; Title compound not separated from byproducts;
DOI:10.1016/j.tetasy.2004.09.010

Reference yield:

: 812665-19-3
3-[2-Phenyl-1-((S)-toluene-4-sulfinyl)-eth-(E)-ylidene]-1-oxa-4-aza-spiro[4.5]decane

: (R_S,2S,3R)-2-(cyclohexylamine)-3-[(4-methylphenyl)sulfinyl]-4-phenylbutan-1-ol

: (R_S,2R,3R)-2-(cyclohexylamine)-3-[(4-methylphenyl)sulfinyl]-4-phenylbutan-1-ol

: (R_S,2S,3S)-2-(cyclohexylamine)-3-[(4-methylphenyl)sulfinyl]-4-phenylbutan-1-ol

: (R_S,2R,3S)-2-(cyclohexylamine)-3-[(4-methylphenyl)sulfinyl]-4-phenylbutan-1-ol

Guidance literature:: With lithium triethylborohydride; In tetrahydrofuran; at 0 - 22 ℃; Title compound not separated from byproducts;
DOI:10.1016/j.tetasy.2004.09.010