N,N′-(6-[(2-methoxyphenyl)amino]pyrido[2,3-d]pyrimidine-2,4-diyl)bis(2,2-dimethylpropanamide)

Base Information

• Chemical Name: N,N′-(6-[(2-methoxyphenyl)amino]pyrido[2,3-d]pyrimidine-2,4-diyl)bis(2,2-dimethylpropanamide)
• CAS No.: 1436870-09-5
• Molecular Formula: C₂₄H₃₀N₆O₃
• Molecular Weight: 450.541

Synonyms:N,N′-(6-[(2-methoxyphenyl)amino]pyrido[2,3-d]pyrimidine-2,4-diyl)bis(2,2-dimethylpropanamide)

Chemical Property of N,N′-(6-[(2-methoxyphenyl)amino]pyrido[2,3-d]pyrimidine-2,4-diyl)bis(2,2-dimethylpropanamide)

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Technology Process of N,N′-(6-[(2-methoxyphenyl)amino]pyrido[2,3-d]pyrimidine-2,4-diyl)bis(2,2-dimethylpropanamide)

There total 2 articles about N,N′-(6-[(2-methoxyphenyl)amino]pyrido[2,3-d]pyrimidine-2,4-diyl)bis(2,2-dimethylpropanamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-methoxy-phenylamine (90-04-0) + 2,4-bis(pivaloylamino)-6-bromopyrido<2,3-d>pyrimidine (138609-27-5) → N,N′-(6-[(2-methoxyphenyl)amino]pyrido[2,3-d]pyrimidine-2,4-diyl)bis(2,2-dimethylpropanamide) (1436870-09-5)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hexamethyldisilazane; XPhos; In toluene; at 100 ℃; for 20h; Sealed tube;

DOI:10.1021/jm400086g

Reference yield:

2,4-diamino-6-bromopyrido<2,3-d>pyrimidine (152941-69-0) → N,N′-(6-[(2-methoxyphenyl)amino]pyrido[2,3-d]pyrimidine-2,4-diyl)bis(2,2-dimethylpropanamide) (1436870-09-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 8 h / Reflux

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hexamethyldisilazane; XPhos / toluene / 20 h / 100 °C / Sealed tube

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hexamethyldisilazane; XPhos; In toluene; 2: |Buchwald-Hartwig Coupling;

DOI:10.1021/jm400086g

Reference yield: 71.0%

N,N′-(6-[(2-methoxyphenyl)amino]pyrido[2,3-d]pyrimidine-2,4-diyl)bis(2,2-dimethylpropanamide) (1436870-09-5) → C14H14N6O (1436869-85-0)

Guidance literature:

With ammonia; In methanol; dichloromethane; at 20 ℃; for 1728h; Sealed tube;

DOI:10.1021/jm400086g

upstream raw materials:

2,4-diamino-6-bromopyrido<2,3-d>pyrimidine

2-methoxy-phenylamine

2,4-bis(pivaloylamino)-6-bromopyrido<2,3-d>pyrimidine

Downstream raw materials:

C₁₄H₁₄N₆O

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