5-[2-(2,6-dichloroanilino) benzyl]-S-(3-methoxyphenacyl)-1,3,4-oxadiazole-2-thiol

Base Information

Chemical Name:5-[2-(2,6-dichloroanilino) benzyl]-S-(3-methoxyphenacyl)-1,3,4-oxadiazole-2-thiol
CAS No.:1016229-42-7
Molecular Formula:C₂₄H₁₉Cl₂N₃O₃S
Molecular Weight:500.405
Hs Code.:

Synonyms:5-[2-(2,6-dichloroanilino) benzyl]-S-(3-methoxyphenacyl)-1,3,4-oxadiazole-2-thiol

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Chemical Property of 5-[2-(2,6-dichloroanilino) benzyl]-S-(3-methoxyphenacyl)-1,3,4-oxadiazole-2-thiol

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Technology Process of 5-[2-(2,6-dichloroanilino) benzyl]-S-(3-methoxyphenacyl)-1,3,4-oxadiazole-2-thiol

There total 6 articles about 5-[2-(2,6-dichloroanilino) benzyl]-S-(3-methoxyphenacyl)-1,3,4-oxadiazole-2-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 133239-19-7
5-({2'-[(2'',6''-dichlorophenyl)amino]phenyl}methyl)-1,3,4-oxadiazole-2-thiol

: 1016229-42-7
5-[2-(2,6-dichloroanilino) benzyl]-S-(3-methoxyphenacyl)-1,3,4-oxadiazole-2-thiol

Guidance literature:: With triethylamine; In ethanol; at 100 ℃; for 5h;
DOI:10.2174/1573406414666180321141555

Reference yield: 71.0%

: 586-37-8
1-(3-Methoxyphenyl)ethanone

: 133239-19-7
5-({2'-[(2'',6''-dichlorophenyl)amino]phenyl}methyl)-1,3,4-oxadiazole-2-thiol

: 1016229-42-7
5-[2-(2,6-dichloroanilino) benzyl]-S-(3-methoxyphenacyl)-1,3,4-oxadiazole-2-thiol

Guidance literature:: With pyridine; Heating;
DOI:10.1016/j.bmc.2007.11.014

Reference yield:

: 15307-79-6
diclofenac sodium

: 1016229-42-7
5-[2-(2,6-dichloroanilino) benzyl]-S-(3-methoxyphenacyl)-1,3,4-oxadiazole-2-thiol

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / water

2: sulfuric acid / 0.25 h / Reflux

3: hydrazine hydrate / methanol / 48 h / Cooling with ice

4: potassium hydroxide / ethanol / 24 h / Reflux

5: triethylamine / ethanol / 5 h / 100 °C

With hydrogenchloride; sulfuric acid; hydrazine hydrate; triethylamine; potassium hydroxide; In methanol; ethanol; water;
DOI:10.2174/1573406414666180321141555