2-(2-Fluoro-phenyl)-8-trifluoromethyl-quinoline-4-carboxylic acid

Base Information

• Chemical Name: 2-(2-Fluoro-phenyl)-8-trifluoromethyl-quinoline-4-carboxylic acid
• CAS No.: 148887-60-9
• Molecular Formula: C₁₇H₉F₄NO₂
• Molecular Weight: 335.258
• Mol file: 148887-60-9.mol

Synonyms:2-(2-Fluoro-phenyl)-8-trifluoromethyl-quinoline-4-carboxylic acid

Chemical Property of 2-(2-Fluoro-phenyl)-8-trifluoromethyl-quinoline-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-(2-Fluoro-phenyl)-8-trifluoromethyl-quinoline-4-carboxylic acid

There total 1 articles about 2-(2-Fluoro-phenyl)-8-trifluoromethyl-quinoline-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

7-trifluoromethylisatin (391-12-8) + 2'-Fluoroacetophenone (445-27-2) → 2-(2-Fluoro-phenyl)-8-trifluoromethyl-quinoline-4-carboxylic acid (148887-60-9)

Guidance literature:

With potassium hydroxide; In ethanol; at 50 - 60 ℃; for 14h;

DOI:10.1016/0223-5234(92)90032-V

Reference yield: 57.0%

Sarcosine ethyl ester (13200-60-7) + 2-(2-Fluoro-phenyl)-8-trifluoromethyl-quinoline-4-carboxylic acid (148887-60-9) → {[2-(2-Fluoro-phenyl)-8-trifluoromethyl-quinoline-4-carbonyl]-methyl-amino}-acetic acid ethyl ester (148887-69-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; acetonitrile; for 4h; Ambient temperature;

DOI:10.1016/0223-5234(92)90032-V

Reference yield:

2-(2-Fluoro-phenyl)-8-trifluoromethyl-quinoline-4-carboxylic acid (148887-60-9) → {[2-(2-Fluoro-phenyl)-8-trifluoromethyl-quinoline-4-carbothioyl]-methyl-amino}-acetic acid

Guidance literature:

Multi-step reaction with 3 steps

1: 57 percent / N,N'-dicyclohexyl carbodiimide / tetrahydrofuran; acetonitrile / 4 h / Ambient temperature

2: 75 percent / Lawesson's reagent / toluene / 3 h / Heating

3: 61 percent / aq. NaOH / methanol; tetrahydrofuran / 10 h / Ambient temperature

With Lawessons reagent; sodium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; toluene; acetonitrile;

DOI:10.1016/0223-5234(92)90032-V

upstream raw materials:

7-trifluoromethylisatin

2'-Fluoroacetophenone

Downstream raw materials:

{[2-(2-Fluoro-phenyl)-8-trifluoromethyl-quinoline-4-carbonyl]-methyl-amino}-acetic acid ethyl ester

{[2-(2-Fluoro-phenyl)-8-trifluoromethyl-quinoline-4-carbothioyl]-methyl-amino}-acetic acid ethyl ester