3-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-5-nitrophenol

Base Information

Chemical Name:3-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-5-nitrophenol
CAS No.:1509919-73-6
Molecular Formula:C₁₉H₁₅N₅O₅
Molecular Weight:393.359
Hs Code.:

Synonyms:3-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-5-nitrophenol

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Chemical Property of 3-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-5-nitrophenol

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Technology Process of 3-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-5-nitrophenol

There total 11 articles about 3-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-5-nitrophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.6%

: 1509920-01-7
2-(3-methoxy-5-nitrophenyl)-4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidine

: 1509919-73-6
3-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-5-nitrophenol

Guidance literature:: With water; hydrogen bromide; In acetic acid; at 80 ℃; for 48h;
DOI:10.1021/ml400378e

Reference yield:

: 1509919-87-2
3-(3-methoxy-5-nitrobenzamido)furo[2,3-b]pyridine-2-carboxamide

: 1509919-73-6
3-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-5-nitrophenol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / isopropyl alcohol / 4 h / Reflux

2: trichlorophosphate / 4 h / 110 °C / Cooling with ice

3: toluene / 4 h / 0 - 135 °C

4: hydrogen bromide; water / acetic acid / 48 h / 80 °C

With water; hydrogen bromide; sodium hydroxide; trichlorophosphate; In acetic acid; isopropyl alcohol; toluene;
DOI:10.1021/ml400378e

Reference yield:

: 6602-54-6
2-chloro-3-pyridinecarbonitrile

: 1509919-73-6
3-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-5-nitrophenol

Guidance literature:: Multi-step reaction with 9 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 75 °C

2: pyridine / tetrahydrofuran / 0 - 20 °C

3: sodium hydroxide; water / ethanol / 20 °C

4: thionyl chloride / 6 h / Reflux

5: ammonium hydroxide / methanol / 6 h / 50 °C

6: sodium hydroxide / isopropyl alcohol / 4 h / Reflux

7: trichlorophosphate / 4 h / 110 °C / Cooling with ice

8: toluene / 4 h / 0 - 135 °C

9: hydrogen bromide; water / acetic acid / 48 h / 80 °C

With pyridine; ammonium hydroxide; thionyl chloride; water; hydrogen bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; acetic acid; isopropyl alcohol; toluene;
DOI:10.1021/ml400378e