2-(1-(4-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methoxy)butyl)piperidin-4-yl)benzo[d]oxazole

Base Information

Chemical Name:2-(1-(4-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methoxy)butyl)piperidin-4-yl)benzo[d]oxazole
CAS No.:1596340-59-8
Molecular Formula:C₃₁H₃₄N₂O₄
Molecular Weight:498.622
Hs Code.:

Synonyms:2-(1-(4-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methoxy)butyl)piperidin-4-yl)benzo[d]oxazole

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Chemical Property of 2-(1-(4-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methoxy)butyl)piperidin-4-yl)benzo[d]oxazole

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Technology Process of 2-(1-(4-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methoxy)butyl)piperidin-4-yl)benzo[d]oxazole

There total 6 articles about 2-(1-(4-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methoxy)butyl)piperidin-4-yl)benzo[d]oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51784-03-3
4-(benzoxazol-2-yl)piperidine

: 1596340-51-0
2-((4-bromobutoxy)methyl)-2,3-dihydro-3-phenyl-benzo[b][1,4]dioxane

: 1596340-59-8
2-(1-(4-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methoxy)butyl)piperidin-4-yl)benzo[d]oxazole

Guidance literature:: With potassium carbonate; In acetone; for 12h; Reflux;
DOI:10.1016/j.bmcl.2014.02.031

Reference yield:

: 24127-63-7
(2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methanol

: 1596340-59-8
2-(1-(4-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methoxy)butyl)piperidin-4-yl)benzo[d]oxazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water; dimethyl sulfoxide / 10 h / 60 °C

2: potassium carbonate / acetone / 12 h / Reflux

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; sodium hydroxide; In water; dimethyl sulfoxide; acetone;
DOI:10.1016/j.bmcl.2014.02.031

Reference yield:

: 103-26-4,1754-62-7
methyl cinnamate

: 1596340-59-8
2-(1-(4-((2,3-dihydro-2-phenylbenzo[b][1,4]dioxin-3-yl)methoxy)butyl)piperidin-4-yl)benzo[d]oxazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / dichloromethane / 20 °C

2.1: potassium carbonate / acetone / 0.25 h / Reflux; Heating

2.2: 1 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

4.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water; dimethyl sulfoxide / 10 h / 60 °C

5.1: potassium carbonate / acetone / 12 h / Reflux

With lithium aluminium tetrahydride; N-benzyl-N,N,N-triethylammonium chloride; bromine; potassium carbonate; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; acetone;
DOI:10.1016/j.bmcl.2014.02.031