(S)-2-(3-(1-methoxypropan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one

Base Information

Chemical Name:(S)-2-(3-(1-methoxypropan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one
CAS No.:1352570-47-8
Molecular Formula:C₂₁H₂₂N₂O₆S
Molecular Weight:430.481
Hs Code.:

Synonyms:(S)-2-(3-(1-methoxypropan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one

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Chemical Property of (S)-2-(3-(1-methoxypropan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one

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Technology Process of (S)-2-(3-(1-methoxypropan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one

There total 10 articles about (S)-2-(3-(1-methoxypropan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352571-50-6
4-(4-methoxybenzyloxy)-2-(3-((S)-1-methoxypropan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidine

: 1352570-47-8
(S)-2-(3-(1-methoxypropan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; methanol; at 20 ℃;

Reference yield:

: 136-36-7
benzoate d'hydroxy-3 phenyle

: 1352570-47-8
(S)-2-(3-(1-methoxypropan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 - 20 °C

2.2: 1 h / 0 °C / Reflux

3.1: 1H-imidazole / dichloromethane / 0.75 h / 0 - 20 °C

4.1: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tert-butyl methyl ether / 10 h / 100 °C / Inert atmosphere; Microwave irradiation; Sealed tube

5.1: water; sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

6.1: potassium carbonate / N,N-dimethyl-formamide / 120 °C / Sealed tube

7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

7.2: 4 h / 55 °C

8.1: hydrogenchloride; water / 1,4-dioxane; methanol / 20 °C

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; water; sodium hydride; sodium carbonate; potassium carbonate; triphenylphosphine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide; acetonitrile; mineral oil; 1.1: Mitsunobu reaction / 5.1: Suzuki Coupling;

Reference yield:

: 1352571-25-5
(S)-3-(1-methoxy-1-oxopropan-2-yloxy)phenyl benzoate

: 1352570-47-8
(S)-2-(3-(1-methoxypropan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 - 20 °C

1.2: 1 h / 0 °C / Reflux

2.1: 1H-imidazole / dichloromethane / 0.75 h / 0 - 20 °C

3.1: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tert-butyl methyl ether / 10 h / 100 °C / Inert atmosphere; Microwave irradiation; Sealed tube

4.1: water; sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

5.1: potassium carbonate / N,N-dimethyl-formamide / 120 °C / Sealed tube

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

6.2: 4 h / 55 °C

7.1: hydrogenchloride; water / 1,4-dioxane; methanol / 20 °C

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; water; sodium hydride; sodium carbonate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide; acetonitrile; mineral oil; 4.1: Suzuki Coupling;