4-(4-methoxybenzyloxy)-2-(3-((S)-1-methoxypropan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidine

Base Information

Chemical Name:4-(4-methoxybenzyloxy)-2-(3-((S)-1-methoxypropan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidine
CAS No.:1352571-50-6
Molecular Formula:C₂₉H₃₀N₂O₇S
Molecular Weight:550.632
Hs Code.:

Synonyms:4-(4-methoxybenzyloxy)-2-(3-((S)-1-methoxypropan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidine

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Chemical Property of 4-(4-methoxybenzyloxy)-2-(3-((S)-1-methoxypropan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidine

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Technology Process of 4-(4-methoxybenzyloxy)-2-(3-((S)-1-methoxypropan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidine

There total 11 articles about 4-(4-methoxybenzyloxy)-2-(3-((S)-1-methoxypropan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352571-42-6
(2S)-2-(3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenoxy)propan-1-ol

: 74-88-4
methyl iodide

: 1352571-50-6
4-(4-methoxybenzyloxy)-2-(3-((S)-1-methoxypropan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidine

Guidance literature:: (2S)-2-(3-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenoxy)propan-1-ol; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.166667h;

methyl iodide; In tetrahydrofuran; mineral oil; at 55 ℃; for 4h;

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 1352571-50-6
4-(4-methoxybenzyloxy)-2-(3-((S)-1-methoxypropan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium t-butanolate / tetrahydrofuran / 1 h / Reflux

1.2: 2 h / -70 - 20 °C

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 70 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 120 °C / Sealed tube

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

6.2: 4 h / 55 °C

With di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; sodium hydride; sodium carbonate; potassium carbonate; triphenylphosphine; sodium t-butanolate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil; 2.1: Suzuki Coupling / 4.1: Mitsunobu reaction;

Reference yield:

: 480998-38-7
2-chloro-4-((4-methoxybenzyl)oxy)pyrimidine

: 1352571-50-6
4-(4-methoxybenzyloxy)-2-(3-((S)-1-methoxypropan-2-yloxy)-5-(4-(methylsulfonyl)phenoxy)phenyl)pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 70 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 120 °C / Sealed tube

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

5.2: 4 h / 55 °C

With di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; sodium hydride; sodium carbonate; potassium carbonate; triphenylphosphine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil; 1.1: Suzuki Coupling / 3.1: Mitsunobu reaction;