(2S,4S,5R)-4-Methyl-5-phenyl-3-carbobenzyloxy-2-<(E)-2-carboxy>ethyloxazolidine

Base Information

Chemical Name:(2S,4S,5R)-4-Methyl-5-phenyl-3-carbobenzyloxy-2-<(E)-2-carboxy>ethyloxazolidine
CAS No.:129611-51-4
Molecular Formula:C₂₁H₂₁NO₅
Molecular Weight:367.401
Hs Code.:

Synonyms:(2S,4S,5R)-4-Methyl-5-phenyl-3-carbobenzyloxy-2-<(E)-2-carboxy>ethyloxazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S,5R)-4-Methyl-5-phenyl-3-carbobenzyloxy-2-<(E)-2-carboxy>ethyloxazolidine

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Technology Process of (2S,4S,5R)-4-Methyl-5-phenyl-3-carbobenzyloxy-2-<(E)-2-carboxy>ethyloxazolidine

There total 1 articles about (2S,4S,5R)-4-Methyl-5-phenyl-3-carbobenzyloxy-2-<(E)-2-carboxy>ethyloxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.5%

: 120810-76-6
(2S,4S,5R)-4-Methyl-2-((E)-3-oxo-propenyl)-5-phenyl-oxazolidine-3-carboxylic acid benzyl ester

: 129611-51-4
(2S,4S,5R)-4-Methyl-5-phenyl-3-carbobenzyloxy-2-<(E)-2-carboxy>ethyloxazolidine

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; In water; tert-butyl alcohol; Ambient temperature;
DOI:10.1016/S0040-4020(01)89766-0

Reference yield:

: 129611-51-4
(2S,4S,5R)-4-Methyl-5-phenyl-3-carbobenzyloxy-2-<(E)-2-carboxy>ethyloxazolidine

: 129611-59-2
2-((S)-2-Benzyloxy-2-[1,3]dithiolan-2-yl-ethyl)-2-methyl-[1,3]dithiolane

Guidance literature:: Multi-step reaction with 7 steps

1: 1. KOH, 2. Bu₄NHSO₄ / 1. methanol, RT, 5min; 2. CH₃CN, RT, overnight

2: 1. KH / 2. THF, RT, 18h; or with NaH

3: 90 percent / aq. NaOH / methanol / 72 h / Ambient temperature

4: (COCl)2, pyridine / benzene / Ambient temperature

5: diethyl ether / -78 - 0 °C

6: 1. ZnI₂ / 1. Et₂O, 5min; 2. 2h

7: BF₃*Et₂O / CH₂Cl₂ / Ambient temperature

With pyridine; potassium hydroxide; sodium hydroxide; oxalyl dichloride; boron trifluoride diethyl etherate; tetra(n-butyl)ammonium hydrogensulfate; potassium hydride; zinc(II) iodide; In methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0040-4020(01)89766-0

Reference yield:

: 129611-51-4
(2S,4S,5R)-4-Methyl-5-phenyl-3-carbobenzyloxy-2-<(E)-2-carboxy>ethyloxazolidine

: 129611-56-9
(2S,4S,5R)-4-Methyl-5-phenyl-3-carbobenzyloxy-2-<(1S)-1-benzyloxy-2-carbomethyl>ethyloxazolidine

Guidance literature:: Multi-step reaction with 5 steps

1: 1. KOH, 2. Bu₄NHSO₄ / 1. methanol, RT, 5min; 2. CH₃CN, RT, overnight

2: 1. KH / 2. THF, RT, 18h; or with NaH

3: 90 percent / aq. NaOH / methanol / 72 h / Ambient temperature

4: (COCl)2, pyridine / benzene / Ambient temperature

5: diethyl ether / -78 - 0 °C

With pyridine; potassium hydroxide; sodium hydroxide; oxalyl dichloride; tetra(n-butyl)ammonium hydrogensulfate; potassium hydride; In methanol; diethyl ether; benzene;
DOI:10.1016/S0040-4020(01)89766-0