Technology Process of 1-[(1S)-1-methyl-2-(phenylmethoxy)ethyl](2S,1R)-1-methoxy-2-methylbut-3-ene
There total 2 articles about 1-[(1S)-1-methyl-2-(phenylmethoxy)ethyl](2S,1R)-1-methoxy-2-methylbut-3-ene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-benzyloxy-2(S),4(S)-dimethyl-hex-5-en-3(R)-ol;
With
potassium hydride;
In
tetrahydrofuran;
at -5 ℃;
for 0.5h;
methyl iodide;
In
tetrahydrofuran;
at 20 ℃;
for 2.5h;
Further stages.;
DOI:10.1021/ol015531m
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 89 percent / TiCl4
2.1: KH / tetrahydrofuran / 0.5 h / -5 °C
2.2: 92 percent / tetrahydrofuran / 2.5 h / 20 °C
With
titanium tetrachloride; potassium hydride;
In
tetrahydrofuran;
DOI:10.1021/ol015531m
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 9-BBN / tetrahydrofuran / 6 h / sonication
1.2: 88 percent / H2O2 / methanol; tetrahydrofuran; various solvent(s)
2.1: TPAP; NMO; 4 Angstroem molecular sieves / CH2Cl2 / 1.5 h / 0 °C
3.1: 1.6 g / PPh3 / CH2Cl2 / 0.5 h / -78 °C
4.1: n-BuLi / tetrahydrofuran; various solvent(s) / 1 h / -78 °C
4.2: 99 percent / DMPU / tetrahydrofuran; various solvent(s) / 1 h
5.1: 84 percent / Li; NH3 / tetrahydrofuran / 3.33 h / -78 - -40 °C
6.1: TPAP; NMO; 4 Angstroem molecular sieves / CH2Cl2 / 0.5 h / 0 °C
7.1: 398 mg / BF3*Et2O / CH2Cl2 / 1 h / -90 °C
8.1: 16 mg / SmI2 / tetrahydrofuran; methanol / 14 h / -16 °C
9.1: p-toluenesulphonic acid / CH2Cl2 / 6 h
With
9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; N-methyl-2-indolinone; samarium diiodide; tetrapropylammonium perruthennate; 4 A molecular sieve; boron trifluoride diethyl etherate; ammonia; lithium; triphenylphosphine;
toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ol015531m
