N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine, dilithium salt

Base Information

• Chemical Name: N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine, dilithium salt
• CAS No.: 76228-61-0
• Molecular Formula: C₁₈H₁₉N₂O₆P*2Li
• Molecular Weight: 404.214
• Mol file: 76228-61-0.mol

Synonyms:N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine, dilithium salt

Chemical Property of N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine, dilithium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine, dilithium salt

There total 4 articles about N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine, dilithium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine methyl ester (76203-92-4) → N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine, dilithium salt (76228-61-0)

Guidance literature:

With lithium hydroxide; In acetonitrile; at 21 ℃; for 24h; Yield given;

DOI:10.1021/ja00393a026

Reference yield:

dimethyl N-(benzyloxycarbonyl)aminomethylphosphonate (59191-35-4) → N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine, dilithium salt (76228-61-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 68 percent / 2N NaOH, 2N H₂SO₄ / 0.75 h / 21 °C

2: SOCl₂ / CHCl₃ / 4 h / 21 °C

3: Et₃N / CHCl₃ / 0.33 h / 21 °C

4: LiOH / acetonitrile / 24 h / 21 °C

With lithium hydroxide; sodium hydroxide; thionyl chloride; sulfuric acid; triethylamine; In chloroform; acetonitrile;

DOI:10.1021/ja00393a026

Reference yield:

methyl N-(benzyloxycarbonyl)aminomethylphosphonochloridate (80556-22-5) → N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine, dilithium salt (76228-61-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CHCl₃ / 0.33 h / 21 °C

2: LiOH / acetonitrile / 24 h / 21 °C

With lithium hydroxide; triethylamine; In chloroform; acetonitrile;

DOI:10.1021/ja00393a026

upstream raw materials:

N-<<<(benzyloxycarbonyl)amino>methyl>methoxyphosphinyl>-L-phenylalanine methyl ester

dimethyl N-(benzyloxycarbonyl)aminomethylphosphonate

methyl N-(benzyloxycarbonyl)aminomethylphosphonochloridate

methyl <(N-carbobenzoxyamino)methyl>phosphonic acid

Downstream raw materials:

Phenylalanine

N-(benzyloxycarbonyl)aminomethylphosphonic acid