(4-hydroxy-5-isopropyl-2-methoxy-phenyl)-[5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindol-2-yl]-methanone

Base Information

Chemical Name:(4-hydroxy-5-isopropyl-2-methoxy-phenyl)-[5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindol-2-yl]-methanone
CAS No.:1191108-20-9
Molecular Formula:C₂₅H₃₃N₃O₃
Molecular Weight:423.555
Hs Code.:

Synonyms:(4-hydroxy-5-isopropyl-2-methoxy-phenyl)-[5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindol-2-yl]-methanone

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Chemical Property of (4-hydroxy-5-isopropyl-2-methoxy-phenyl)-[5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindol-2-yl]-methanone

Chemical Property:

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Technology Process of (4-hydroxy-5-isopropyl-2-methoxy-phenyl)-[5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindol-2-yl]-methanone

There total 7 articles about (4-hydroxy-5-isopropyl-2-methoxy-phenyl)-[5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindol-2-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 912545-08-5
2,4-bis-benzyloxy-5-isopropenyl-benzoic acid methyl ester

: 1191108-20-9
(4-hydroxy-5-isopropyl-2-methoxy-phenyl)-[5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindol-2-yl]-methanone

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen / palladium 10% on activated carbon / methanol; ethanol / 20 °C

2: potassium carbonate / acetonitrile / 24 h / 20 °C

3: potassium carbonate / acetonitrile / 16 h / Reflux

4: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C

5: water; potassium hydroxide / methanol / 4 h / Reflux

6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 - 80 °C

With water; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; palladium 10% on activated carbon; In methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1191108-50-5
4-hydroxy-5-isopropyl-2-methoxybenzoic acid

: 5-((4-methylpiperazin-1-yl)methyl)iso-indoline trihydrochloride

: 1191108-20-9
(4-hydroxy-5-isopropyl-2-methoxy-phenyl)-[5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindol-2-yl]-methanone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 - 80 ℃;

Reference yield:

: 943519-37-7
2,4-dihydroxy-5-isopropylbenzoic acid methyl ester

: 1191108-20-9
(4-hydroxy-5-isopropyl-2-methoxy-phenyl)-[5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindol-2-yl]-methanone

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile / 24 h / 20 °C

2: potassium carbonate / acetonitrile / 16 h / Reflux

3: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C

4: water; potassium hydroxide / methanol / 4 h / Reflux

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 - 80 °C

With water; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide; acetonitrile;