Methyl 2,4-dihydroxy-5-isopropylbenzoate

Base Information

• Chemical Name: Methyl 2,4-dihydroxy-5-isopropylbenzoate
• CAS No.: 943519-37-7
• Molecular Formula: C11H14O4
• Molecular Weight: 210.23
• Hs Code.: 2918199090
• Mol file: 943519-37-7.mol

Synonyms:Methyl 2,4-dihydroxy-5-isopropylbenzoate;

Chemical Property of Methyl 2,4-dihydroxy-5-isopropylbenzoate

Chemical Property:

• PSA: 66.76000
• LogP: 2.00780
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Methyl2,4-dihydroxy-5-isopropylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2,4-dihydroxy-5-isopropylbenzoate

There total 4 articles about Methyl 2,4-dihydroxy-5-isopropylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,4-bis-benzyloxy-5-isopropenyl-benzoic acid methyl ester (912545-08-5) → 2,4-dihydroxy-5-isopropylbenzoic acid methyl ester (943519-37-7)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; ethanol; at 20 ℃;

Reference yield: 66.0%

isopropyl chloride (75-29-6) + methyl 2,4-dihydroxybenzoate (2150-47-2) → 2,4-dihydroxy-5-isopropylbenzoic acid methyl ester (943519-37-7)

Guidance literature:

With aluminum (III) chloride; In 1,2-dichloro-ethane; at 20 ℃; for 48h;

DOI:10.1039/d1ob01614h

Reference yield: 45.0%

methyl 2,4-dihydroxybenzoate (2150-47-2) + isopropyl bromide (75-26-3) → 2,4-dihydroxy-5-isopropylbenzoic acid methyl ester (943519-37-7)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 50 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.ejmech.2016.10.038

upstream raw materials:

2,4-bis-benzyloxy-5-isopropenyl-benzoic acid methyl ester

4-hydroxysalicylic acid

methyl 2,4-dihydroxybenzoate

isopropyl bromide

Downstream raw materials:

2,4-bisbenzyloxy-5-isopropylbenzoic acid methyl ester

methyl 4-benzyloxy-2-hydroxy-5-isopropylbenzoate

methyl 4-allyloxy-2-hydroxy-5-isopropylbenzoate

methyl 2,4-bis(allyloxy)-5-isopropylbenzoate

Refernces

• 1、 Khlebnicova, Tatyana S.,Lakhvich, Fedor A.,Matous, Anton E.,Piven, Yuri A.,Scherbakov, Alexander M.,Shchegolev, Yuri Yu.,Sorokin, Danila V.,Yastrebova, Margarita A.,Zinovich, Veronica G.. "Effective synthesis of novel dihydrobenzisoxazoles bearing the 2-aminothiazole moiety and evaluation of the antiproliferative activity of their acylated derivatives". . p. 10432 - 10443. Retrieved 2021/12/17.
• 2、 Qin, Feifei,Wang, Yali,Jiang, Xian,Wang, Yujia,Zhang, Nan,Wen, Xiang,Wang, Lian,Jiang, Qinglin,He, Gu. "Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma". . p. 909 - 926. Retrieved 2019/04/13.