2-bromo-4-methoxy-5-hydroxylphenylacetic acid

Base Information

• Chemical Name: 2-bromo-4-methoxy-5-hydroxylphenylacetic acid
• CAS No.: 81038-48-4
• Molecular Formula: C₉H₉BrO₄
• Molecular Weight: 261.072
• Mol file: 81038-48-4.mol

Synonyms:2-bromo-4-methoxy-5-hydroxylphenylacetic acid

Chemical Property of 2-bromo-4-methoxy-5-hydroxylphenylacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-bromo-4-methoxy-5-hydroxylphenylacetic acid

There total 4 articles about 2-bromo-4-methoxy-5-hydroxylphenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

homoisovanillic acid (1131-94-8) → 2-bromo-4-methoxy-5-hydroxylphenylacetic acid (81038-48-4)

Guidance literature:

With bromine; acetic acid; at 20 ℃;

DOI:10.1016/j.tet.2005.05.055

Reference yield: 91.0%

2-bromo-5-hydroxy-4-methoxyphenyl-acetonitrile (81038-45-1) → 2-bromo-4-methoxy-5-hydroxylphenylacetic acid (81038-48-4)

Guidance literature:

With sodium hydroxide;

DOI:10.1002/ardp.19813141203

Reference yield:

3-hydroxy-4-methoxyphenylacetonitrile (4468-58-0) → 2-bromo-4-methoxy-5-hydroxylphenylacetic acid (81038-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / 2N Br₂ / CH₂Cl₂; acetic acid / 2 h / -30 - -25 °C

2: 91 percent / 2 N aq. NaOH

With sodium hydroxide; bromine; In dichloromethane; acetic acid;

DOI:10.1002/ardp.19813141203

upstream raw materials:

2-bromo-5-hydroxy-4-methoxyphenyl-acetonitrile

homoisovanillic acid

3-hydroxy-4-methoxyphenylacetonitrile

Downstream raw materials:

(2-bromo-5-hydroxy-4-methoxy-phenyl)-acetic acid methyl ester

2-(2-Bromo-5-hydroxy-4-methoxy-phenyl)-N-[2-(4-hydroxy-3-methoxy-phenyl)-ethyl]-acetamide

homoisovanillic acid

2-bromo-5-hydroxy-4-methoxyphenylacetamide