3-(4-(cyclopropylsulfonyl)phenoxy)-5-((3-methylbut-2-en-1-yl)oxy)-N-(5-methylpyrazin-2-yl)benzamide

Base Information

Chemical Name:3-(4-(cyclopropylsulfonyl)phenoxy)-5-((3-methylbut-2-en-1-yl)oxy)-N-(5-methylpyrazin-2-yl)benzamide
CAS No.:1374986-64-7
Molecular Formula:C₂₆H₂₇N₃O₅S
Molecular Weight:493.583
Hs Code.:

Synonyms:3-(4-(cyclopropylsulfonyl)phenoxy)-5-((3-methylbut-2-en-1-yl)oxy)-N-(5-methylpyrazin-2-yl)benzamide

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Chemical Property of 3-(4-(cyclopropylsulfonyl)phenoxy)-5-((3-methylbut-2-en-1-yl)oxy)-N-(5-methylpyrazin-2-yl)benzamide

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Technology Process of 3-(4-(cyclopropylsulfonyl)phenoxy)-5-((3-methylbut-2-en-1-yl)oxy)-N-(5-methylpyrazin-2-yl)benzamide

There total 5 articles about 3-(4-(cyclopropylsulfonyl)phenoxy)-5-((3-methylbut-2-en-1-yl)oxy)-N-(5-methylpyrazin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5521-58-4
5-methylpyrazin-2-amine

: C₂₁H₂₁ClO₅S

: 1374986-64-7
3-(4-(cyclopropylsulfonyl)phenoxy)-5-((3-methylbut-2-en-1-yl)oxy)-N-(5-methylpyrazin-2-yl)benzamide

Guidance literature:: With pyridine; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.03.008

Reference yield:

: 648906-28-9
1-bromo-4-(cyclopropanesulfonyl)benzene

: 1374986-64-7
3-(4-(cyclopropylsulfonyl)phenoxy)-5-((3-methylbut-2-en-1-yl)oxy)-N-(5-methylpyrazin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; copper(I) bromide / 1-methyl-pyrrolidin-2-one / 110 °C / Inert atmosphere

2: lithium hydroxide / tetrahydrofuran; water / 2 h / Reflux

3: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 0 °C / Reflux

4: pyridine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With pyridine; thionyl chloride; 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; N,N-dimethyl-formamide; copper(I) bromide; lithium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; 1: Ullmann condensation;
DOI:10.1016/j.bmc.2012.03.008

Reference yield:

: 1374986-51-2
C₂₁H₂₂O₆S

: 1374986-64-7
3-(4-(cyclopropylsulfonyl)phenoxy)-5-((3-methylbut-2-en-1-yl)oxy)-N-(5-methylpyrazin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 0 °C / Reflux

2: pyridine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With pyridine; thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2012.03.008