5521-58-4

Basic information

• Product Name: 5-METHYL-PYRAZIN-2-YLAMINE
• Synonyms: 5-METHYL-PYRAZIN-2-YLAMINE;2-AMINO-5-METHYL PYRAZINE;5-Methylpyrazin-2-amine;2-AMINO-3-BROMO-5-METHYLPYRAZINE 3-BROMO-5-METHYLPYRAZIN-2-YLAMINE;2-Amino-5-(methyl-d3)-pyrazine;5-METHYL-PYRAZIN-2-Y;5-Methyl pyrazine-2-aMine;Sell-5-Methylpyrazin-2-ylaMine
• CAS NO: 5521-58-4
• Molecular Formula: C₅H₇N₃
• Molecular Weight: 109.13
• Mol File: 5521-58-4.mol
• Article Data: 19

Chemical Properties

• Melting Point: 116-117 °C
• Boiling Point: 244.3 °C at 760 mmHg
• Flash Point: 124.8 °C
• Appearance: /Solid
• Density: 1.155 g/cm³
• Vapor Pressure: 0.0307mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.50±0.10(Predicted)
• CAS DataBase Reference: 5-METHYL-PYRAZIN-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-PYRAZIN-2-YLAMINE(5521-58-4)
• EPA Substance Registry System: 5-METHYL-PYRAZIN-2-YLAMINE(5521-58-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5521-58-4(Hazardous Substances Data)

Usage

Uses

5-Methylpyrazin-2-amine is a thiophene-arylamide derivative which is used as a DprE1 inhibitors with potent antimycobacterial activities.

InChI:InChI=1/C5H7N3/c1-4-2-8-5(6)3-7-4/h2-3H,1H3,(H2,6,8)

Upstream product

• 19994-56-0 2-Amino-3-cyano-5-methylpyrazine 1-oxide 
• 41110-33-2 5-methylpyrazine-2-carboxylic acid methyl ester 
• 1130155-48-4 (E)-4-(dimethylamino)-2-butenoic acid hydrochloride 
• 181284-14-0 3-chloro-5-methylpyrazine-2-carbonitrile 
• 88394-05-2 3-carboxamido-2-hydroxy-6-methylpyrazine 
• 96-26-4 dihydroxyacetone 
• 69816-37-1 2-amino-acetamidine dihydrobromide 
• 141-46-8 Glycolaldehyde 
• 5521-55-1 2-methylpyrazin-5-carboxylic acid 
• 1033418-57-3 benzyl-5-methylpyrazin-2-yl carbamate 
• 109-60-4 1-Propyl acetate 
• 76-05-1 trifluoroacetic acid 
• 369638-68-6 tert-butyl (5-methylpyrazin-2-yl)carbamate 
• 625114-66-1 (5-methylpyrazin-2-yl)-carbamic acid phenyl ester 

Downstream Products

• 823806-59-3 (6-methyl-imidazo[1,2-a]pyrazin-3-yl)-phenyl-amine 
• 823806-72-0 (6-methyl-imidazo[1,2-a]pyrazin-3-ylamino)-acetic acid methyl ester 
• 457097-54-0 3-methoxy-4-[3-(5-methyl-pyrazin-2-yl)-ureido]-benzoic acid methyl ester 
• 457098-11-2 5-methoxy-4-[3-(5-methyl-pyrazin-2-yl)-ureido]-2-trifluoromethyl-benzoic acid methyl ester 
• 919784-87-5 3-{[6-(azetidin-1-ylcarbonyl)pyridin-3-yl]oxy}-5-[((1S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-methylethyl)oxy]-N-(5-methylpyrazin-2-yl)benzamide 
• 919784-91-1 3-{[5-(azetidin-1-ylcarbonyl)-3-chloropyridin-2-yl]oxy}-5-[((1S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-methylethyl)oxy]-N-(5-methylpyrazin-2-yl)benzamide 
• 919783-22-5 AZD₁₆₅₆ 
• 871656-69-8 3-hydroxy-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-N-(5-methylpyrazin-2-yl)benzamide 
• 871656-70-1 3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-N-(5-methylpyrazin-2-yl)-5-[(phenylmethyl)oxy]benzamide 
• 5521-59-5 N-(5-methyl-pyrazin-2-yl)-acetamide 
• 98006-90-7 2-bromo-5-methyl-pyrazine 
• 37830-10-7 5,5'-dimethyl-2,2'-bipyrazine 

Relevant articles and documents

Heterocyclic compound as well as pharmaceutical composition, preparation method, intermediate and application thereof

The invention discloses a heterocyclic compound as well as a pharmaceutical composition, a preparation method, an intermediate and application thereof. The structure of the heterocyclic compound is shown as a formula I, and the heterocyclic compound has CDK7 inhibitory activity and can be used for treating diseases such as tumors.

Synthesis and Characterization of 2-(2-Pyridinyl)pyrazine and 2,2′-Bipyrazine Derivatives

A convenient and high yield preparation of derivatives of 2-(2-pyridinyl)pyrazine and derivatives of 2,2′-bipyrazine compounds from their derivatives of bromopyrazine using Stille coupling is reported. X-ray structures, elemental analyses, 1H, 13C-NMR, and mass spectral data of the compounds are given.

Multimodal Vacuum-Assisted Plasma Ion (VaPI) Source with Transmission Mode and Laser Ablation Sampling Capabilities

We have developed a multimodal ion source design that can be configured on the fly for various analysis modes, designed for more efficient and reproducible sampling at the mass spectrometer atmospheric pressure (AP) interface in a number of different applications. This vacuum-assisted plasma ionization (VaPI) source features interchangeable transmission mode and laser ablation sampling geometries. Operating in both AC and DC power regimes with similar results, the ion source was optimized for parameters including helium flow rate and gas temperature using transmission mode to analyze volatile standards and drug tablets. Using laser ablation, matrix effects were studied, and the source was used to monitor the products of model prebiotic synthetic reactions. [Figure not available: see fulltext.]