bis(1,1-dimethylethyl) [[4-[(2S)-2-fluoro-3-oxo-3-[(4S)-2-oxo-4-phenyl-3-oxazolidinyl]propyl]phenyl]methyl]phosphonate

Base Information

Chemical Name:bis(1,1-dimethylethyl) [[4-[(2S)-2-fluoro-3-oxo-3-[(4S)-2-oxo-4-phenyl-3-oxazolidinyl]propyl]phenyl]methyl]phosphonate
CAS No.:811451-59-9
Molecular Formula:C₂₇H₃₅FNO₆P
Molecular Weight:519.55
Hs Code.:

Synonyms:bis(1,1-dimethylethyl) [[4-[(2S)-2-fluoro-3-oxo-3-[(4S)-2-oxo-4-phenyl-3-oxazolidinyl]propyl]phenyl]methyl]phosphonate

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Chemical Property of bis(1,1-dimethylethyl) [[4-[(2S)-2-fluoro-3-oxo-3-[(4S)-2-oxo-4-phenyl-3-oxazolidinyl]propyl]phenyl]methyl]phosphonate

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Technology Process of bis(1,1-dimethylethyl) [[4-[(2S)-2-fluoro-3-oxo-3-[(4S)-2-oxo-4-phenyl-3-oxazolidinyl]propyl]phenyl]methyl]phosphonate

There total 1 articles about bis(1,1-dimethylethyl) [[4-[(2S)-2-fluoro-3-oxo-3-[(4S)-2-oxo-4-phenyl-3-oxazolidinyl]propyl]phenyl]methyl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 491831-46-0
bis(1,1-dimethylethyl) [[4-[3-oxo-3-[(4S)-2-oxo-4-phenyl-3-oxazolidinyl]propyl]phenyl]methyl]phosphonate

: 811451-59-9
bis(1,1-dimethylethyl) [[4-[(2S)-2-fluoro-3-oxo-3-[(4S)-2-oxo-4-phenyl-3-oxazolidinyl]propyl]phenyl]methyl]phosphonate

Guidance literature:: With sodium hexamethyldisilazane; N-fluorobenzene sulfonamide; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1081/SCC-200034770

Reference yield:

: 811451-59-9
bis(1,1-dimethylethyl) [[4-[(2S)-2-fluoro-3-oxo-3-[(4S)-2-oxo-4-phenyl-3-oxazolidinyl]propyl]phenyl]methyl]phosphonate

: 811451-58-8
(2S)-2-fluoro-4-[[bis(1,1-dimethoxyethoxy)phosphinyl]methyl]benzenepropanoic acid

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 0 - 20 ℃;
DOI:10.1081/SCC-200034770

Reference yield:

: 811451-59-9
bis(1,1-dimethylethyl) [[4-[(2S)-2-fluoro-3-oxo-3-[(4S)-2-oxo-4-phenyl-3-oxazolidinyl]propyl]phenyl]methyl]phosphonate

: [[4-[3-[[1-[[[(1S)-3-amino-1-[[[3-(1-naphthalenyl)propyl]amino]carbonyl]-3-oxopropyl]amino]carbonyl]cyclohexyl]amino]-3-[(2S)-2-fluoro]oxopropyl]phenyl]methyl]phosphonic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen peroxide; lithium hydroxide / tetrahydrofuran; H₂O / 0 - 20 °C

2: 86 percent / 1-hydroxy-7-azabenzotriazole; EDCl*HCl / dimethylformamide / 0 - 20 °C

3: trifluoroacetic acid; SiEt₃ / H₂O / 1 h / 20 °C

With triethylsilane; lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; dihydrogen peroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1081/SCC-200034770